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| | BRL 15572 HYDROCHLORIDE Basic information |
| Product Name: | BRL 15572 HYDROCHLORIDE | | Synonyms: | 3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-ol dihydrochloride;BRL 15572 HYDROCHLORIDE;3-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]-1,1-DIPHENYL-2-PROPANOL HCL;3-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]-1,1-DIPHENYL-2-PROPANOL HYDROCHLORIDE;BRL15572HCl;BRL-15572 (dihydrochloride);4-(3-Chlorophenyl)-alpha-(diphenylmethyl)-1-piperazineethanol dihydrochloride;BRL-15572 dihydrochloride
(BRL15572 | | CAS: | 193611-72-2 | | MF: | C25H28Cl2N2O | | MW: | 443.41 | | EINECS: | | | Product Categories: | Inhibitors;Serotonin receptor | | Mol File: | 193611-72-2.mol |  |
| | BRL 15572 HYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in DMSO | | form | Powder | | color | White to off-white |
| | BRL 15572 HYDROCHLORIDE Usage And Synthesis |
| Uses | BRL 15572 Hydrochloride is an analog of BRL 15572, which is a preferential antagonist at native human 5-HT1D receptors. | | Biological Activity | A selective h5-HT 1D antagonist, displaying 60-fold selectivity over h5-HT 1B , and exhibiting little or no affinity for a range of other receptor types. | | in vivo | BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3]. | | target | 5-HT1D | | IC 50 | 5-HT1D Receptor | | references | [1] price g w, burton m j, collin l j, et al. sb-216641 and brl-15572–compounds to pharmacologically discriminate h5-ht1b and h5-ht1d receptors. naunyn-schmiedeberg's archives of pharmacology, 1997, 356(3): 312-320. |
| | BRL 15572 HYDROCHLORIDE Preparation Products And Raw materials |
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