3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

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Company Name:	CEG Chemical Science&Technology Co., Ltd.
Tel:	Mobile:13665161512
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3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Basic information

Product Name:	3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
Synonyms:	kb-NB142-70 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one;3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one;CS-2453;kbNB142-70, >98%;[1]Benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one, 3,4-dihydro-9-hydroxy-;4-Hydroxy-8,14-dithia-11-azatricyclo[7.5.0.0^{2,7}]tetradeca-1(9),2,4,6-tetraen-10-one;inhibit,kb NB 142-70,Inhibitor,kb NB 14270,PKD,Protein kinase D,kb NB 142 70;9-Hydroxy-3,4-dihydrobenzo[4,5]thieno[2,3-f][1,4]thiazepin-5(2H)-one
CAS:	1233533-04-4
MF:	C11H9NO2S2
MW:	251.32
EINECS:
Product Categories:	Inhibitors
Mol File:	1233533-04-4.mol

3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Chemical Properties

Melting point	235-238℃ (decomposition) (water dichloromethane )
Boiling point	601.9±55.0 °C(Predicted)
density	1.495±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble10mg/mL, clear
pka	8.99±0.20(Predicted)
form	powder
color	white to beige
InChI	1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
InChIKey	DHUAGGSHTKPOHU-UHFFFAOYSA-N
SMILES	Oc1ccc2sc3C(=O)NCCSc3c2c1

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

MSDS Information

3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Usage And Synthesis

Uses	kb NB 142-70 is a potent & selective protein kinase D inhibitor.
Biological Activity	kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145.
IC 50	PKD1: 28.3 nM (IC₅₀); PKD3: 53.2 nM (IC₅₀); PKD2: 58.7 nM (IC₅₀)
storage	Store at RT

3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Preparation Products And Raw materials

Tag:3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one(1233533-04-4) Related Product Information

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