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Product Name:RPR-260243
CAS:668463-35-2
Purity:>98% Package:1466RMB/2mg
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RPR-260243 manufacturers
- RPR-260243
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- $1070.00 / 25mg
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2025-12-09
- CAS:668463-35-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | RPR-260243 Basic information |
| Product Name: | RPR-260243 | | Synonyms: | RPR-260243;(3R,4R)-4-[3-(6-Methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid;(3R,4R)-4-[3-(6-Methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl];100866;RPR 260243;RPR260243;CS-2094;3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-[3-(2,3,5-trifluorophenyl)-2-propyn-1-yl]-, (3R,4R)-;(3r,4r)-4-(3-(6-methoxyquinolin-4-yl)-3-oxopropyl)-1-(3-(2,3,5-trifluorophenyl)prop-2-yn-1-yl)piperidine-3-carboxylic acid | | CAS: | 668463-35-2 | | MF: | C28H25F3N2O4 | | MW: | 510.5 | | EINECS: | | | Product Categories: | | | Mol File: | 668463-35-2.mol |  |
| | RPR-260243 Chemical Properties |
| Boiling point | 668.0±55.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Store at 2-8°C | | solubility | DMSO: 10 mg/mL (19.59 mM) | | form | Solid | | pka | 3.71±0.40(Predicted) | | color | Light yellow to light brown |
| | RPR-260243 Usage And Synthesis |
| Uses | RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC50=58 nM). RPR260243 displays no activator-like effects on other voltage-dependent ion channels, including the closely related ERG3 K+ channel[1][2]. RPR-260243 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | [1] Wu W, et al. Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. Mol Pharmacol. 2015;87(3):401-409. DOI:10.1124/mol.114.096693
[2] Kang J, et al. Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. Mol Pharmacol. 2005;67(3):827-836. DOI:10.1124/mol.104.006577 |
| | RPR-260243 Preparation Products And Raw materials |
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