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| | 5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol Basic information |
| Product Name: | 5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol | | Synonyms: | 5-Methyl-3H-pyrrolo[3,2-d]pyriMidin-4(5H)-one;3,5-dihydro-5-Methyl-4H-Pyrrolo[3,2-d]pyriMidin-4-one;5-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one;4H-Pyrrolo[3,2-d]pyrimidin-4-one, 3,5-dihydro-5-methyl-;5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol | | CAS: | 919278-72-1 | | MF: | C7H7N3O | | MW: | 149.15 | | EINECS: | | | Product Categories: | | | Mol File: | 919278-72-1.mol | ![5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol Structure](CAS/GIF/919278-72-1.gif) |
| | 5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol Chemical Properties |
| Boiling point | 330.0±34.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.84±0.20(Predicted) | | Appearance | Light brown to brown Solid |
| | 5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol Usage And Synthesis |
| Synthesis | 4-Chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (3.30 g, 19.7 mmol) was used as starting material, which was mixed with 6 N aqueous hydrochloric acid (20 mL) and the reaction was stirred for 1 h at 120 °C. The reaction was carried out at 120 °C with the addition of 8 N aqueous sodium hydroxide. Upon completion of the reaction, the reaction solution was cooled to 0 °C and the pH was adjusted slowly to 7 by adding 8 N aqueous sodium hydroxide solution.Subsequently, the reaction mixture was filtered to collect the precipitated solid product, which was washed several times with deionized water, and dried to afford the target compound, 5-methyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (2.60 g, 88% yield), as a yellow solid. The product was characterized by 1H-NMR (DMSO-d6, 300 MHz): δ 3.99 (3H, s), 6.31 (1H, d, J = 2.7 Hz), 7.35 (1H, d, J = 2.7 Hz), 7.73 (1H, d, J = 3.0 Hz), 11.81 (1H, br s). | | References | [1] Patent: WO2007/4749, 2007, A1. Location in patent: Page/Page column 158 |
| | 5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol Preparation Products And Raw materials |
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