- DiMNF
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2026-07-27
- CAS:14756-24-2
- Purity: 97.60%
- Supply Ability: 10g
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| | 3',4'-DiMethoxy-α-naphthoflavone Basic information |
| Product Name: | 3',4'-DiMethoxy-α-naphthoflavone | | Synonyms: | 3',4'-DiMethoxy-α-naphthoflavone;2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one;DiMNF;NSC 123391;2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one;4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)-;2-(3,4-Dimethoxyphenyl)-4H-benzo[h]chromen-4-one | | CAS: | 14756-24-2 | | MF: | C21H16O4 | | MW: | 332.35 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 14756-24-2.mol |  |
| | 3',4'-DiMethoxy-α-naphthoflavone Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥13mg/mL | | form | powder | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | 3',4'-DiMethoxy-α-naphthoflavone Usage And Synthesis |
| Description | DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2Represses estrogen-inducible transcription.3 | | Uses | 3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation. | | Uses | 3'',4''-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation. | | References | [1] IAIN A MURRAY. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone.[J]. Molecular Pharmacology, 2011, 79 3: 508-519. DOI:10.1124/mol.110.069369
[2] GITANJALI A NARAYANAN. Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure.[J]. Journal of Pharmacology and Experimental Therapeutics, 2012, 342 2: 345-355. DOI:10.1124/jpet.112.193482
[3] MARK P LABRECQUE. Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines.[J]. PLoS ONE, 2012: e29545. DOI:10.1371/journal.pone.0029545 |
| | 3',4'-DiMethoxy-α-naphthoflavone Preparation Products And Raw materials |
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