3-chloro-1-Methyl-4-nitro-1H-pyrazole manufacturers
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| | 3-chloro-1-Methyl-4-nitro-1H-pyrazole Basic information |
| | 3-chloro-1-Methyl-4-nitro-1H-pyrazole Chemical Properties |
| Boiling point | 272.9±20.0 °C(Predicted) | | density | 1.65±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -4.59±0.10(Predicted) | | Appearance | Light yellow to yellow Solid |
| | 3-chloro-1-Methyl-4-nitro-1H-pyrazole Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-chloro-1-methyl-4-nitro-1H-pyrazole from 3-chloro-1-methyl-1H-pyrazole: 3-chloro-1-methyl-1H-pyrazole (4.0 g, 34 mmol) was dissolved in concentrated hydrochloric acid and stirred. Fuming nitric acid (3.6 g, 120.0 mmol) was slowly added dropwise to sulfuric acid (4.0 mL) at 0 °C, followed by continuous stirring of the reaction mixture for 6 h at room temperature. Upon completion of the reaction, the reaction was quenched slowly with ice water, at which time a white solid precipitated. The solid product was collected by filtration and dried under vacuum to give 3-chloro-1-methyl-4-nitro-1H-pyrazole (3.0 g, 54% yield) as a final white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.16 (s, 1H), 3.94 (s, 3H). | | References | [1] Patent: WO2010/139731, 2010, A1. Location in patent: Page/Page column 98
[2] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 000130 |
| | 3-chloro-1-Methyl-4-nitro-1H-pyrazole Preparation Products And Raw materials |
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