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| | 8-Methyl-3,4-dihydroisoquinolin-1(2H)-one Basic information |
| | 8-Methyl-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties |
| Boiling point | 404.3±45.0 °C(Predicted) | | density | 1.111±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.73±0.20(Predicted) | | Appearance | White to off-white Solid |
| | 8-Methyl-3,4-dihydroisoquinolin-1(2H)-one Usage And Synthesis |
| Synthesis | 8-Methylisoquinolin-1(2H)-one (76a, 1 g, 6.29 mmol) was used as raw material and mixed with 10% Pd/C (0.5 g) in methanol (20 mL). The mixture was subjected to hydrogenation reaction under hydrogen (60 psi) atmosphere at 80°C for 48 hours. Upon completion of the reaction, the reaction mixture was filtered and the solid catalyst was washed with methanol (2 x 20 mL). The filtrate was concentrated under vacuum to afford the target product 8-methyl-3,4-dihydroisoquinolin-1(2H)-one (76b, 1 g, ~100% yield) as a gray solid. | | References | [1] Patent: US2014/179667, 2014, A1. Location in patent: Paragraph 0874; 0876 |
| | 8-Methyl-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials |
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