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| | N,N-Dimethyl-3-fluoroaniline Basic information |
| Product Name: | N,N-Dimethyl-3-fluoroaniline | | Synonyms: | 1-Fluoro-3-(dimethylamino)benzene;3-Fluoro-N,N-diMethylaniline;1-(DIMETHYLAMINO)-3-FLUOROBENZENE;Benzenamine, 3-fluoro-2,4-dimethyl-;Benzenamine, 3-fluoro-N,N-dimethyl-;3-Fluoro-N,N-dimethyl-benzenamine;N,N-Dimethyl-3-fluoroaniline | | CAS: | 2107-43-9 | | MF: | C8H10FN | | MW: | 139.17 | | EINECS: | | | Product Categories: | | | Mol File: | 2107-43-9.mol |  |
| | N,N-Dimethyl-3-fluoroaniline Chemical Properties |
| Boiling point | 198-199 °C(Press: 752 Torr) | | density | 1.057±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.991±0.10(predicted) |
| Hazard Codes | Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36/37/39 | | RIDADR | 1993 | | Hazard Note | Irritant | | HazardClass | 3 | | PackingGroup | Ⅲ | | HS Code | 2921490090 |
| | N,N-Dimethyl-3-fluoroaniline Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-fluoro-N,N-dimethylaniline from carbon dioxide and 3-fluoro-N-methylaniline was as follows: the methylation of various secondary amines was carried out using the general method Example II. The specific operating conditions were as follows: the substituted aromatic amines (1.0 mmol), [Ru(Triphos)(TMM)] (2.5 mol%), and HNTf2 (5 mol%) were dissolved in THF (2 mL), and reacted at 150 °C under a CO2/H2 (20/60 bar) atmosphere. The reaction time and yield data are detailed in Table II below.The reaction times and corresponding yields for different amine substrates are listed in Table II. | | References | [1] Patent: WO2015/753, 2015, A1. Location in patent: Page/Page column 8-9
[2] Chemical Science, 2013, vol. 4, # 5, p. 2127 - 2131
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 36, p. 9554 - 9557
[4] Angew. Chem., 2013, vol. 125, # 36, p. 9733 - 9736
[5] Patent: EP2821397, 2015, A1. Location in patent: Paragraph 0039; 0041 |
| | N,N-Dimethyl-3-fluoroaniline Preparation Products And Raw materials |
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