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BOC Sciences |
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| Company Name: |
Sigma-Aldrich |
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POLYGODIAL manufacturers
- Polygodial
-
- $42.00
-
2026-07-15
- CAS:6754-20-7
- Purity: 99.84%
- Supply Ability: 10g
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| | POLYGODIAL Basic information |
| Product Name: | POLYGODIAL | | Synonyms: | (-)-Tadeonal;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (1R-(1alpha,4abeta,8aalpha))-;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;Drim-7-ene-11,12-dial;Poligodial;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde | | CAS: | 6754-20-7 | | MF: | C15H22O2 | | MW: | 234.33 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 6754-20-7.mol |  |
| | POLYGODIAL Chemical Properties |
| Melting point | 57° (Barnes, Loder) | | alpha | D24 -131° (c = 0.96 in ethanol) | | Boiling point | 330.7±35.0 °C(Predicted) | | density | 1.084±0.06 g/cm3(Predicted) | | RTECS | QJ2850000 | | storage temp. | -20°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | color | white to beige | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. | | InChI | 1S/C15H22O2/c1-14(2)7-4-8-15(3)12(10-17)11(9-16)5-6-13(14)15/h5,9-10,12-13H,4,6-8H2,1-3H3/t12-,13-,15+/m0/s1 | | InChIKey | AZJUJOFIHHNCSV-KCQAQPDRSA-N | | SMILES | O=C[C@@H]1[C@@]2([C@H](C(CCC2)(C)C)CC=C1C=O)C | | LogP | 3.522 (est) |
| Risk Statements | 52/53 | | Safety Statements | 61 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | POLYGODIAL Usage And Synthesis |
| Description | Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2 | | Uses | Polygodial is a naturally occurring antifungal and antinociceptive. | | Definition | ChEBI: Polygodial is an aldehyde. | | Biochem/physiol Actions | Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae. | | storage | Store at -20°C | | References | [1] JASMINE ESCALERA. TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.[J]. The Journal of Biological Chemistry, 2008, 283 35: 24136-24144. DOI:10.1074/jbc.m710280200
[2] EUNICE ANDRE . Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats[J]. Neuropharmacology, 2004, 46 4: Pages 590-597. DOI:10.1016/j.neuropharm.2003.10.008 |
| | POLYGODIAL Preparation Products And Raw materials |
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