- 4-Bromo-3,5-dimethylphenol
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- $15.00 / 1KG
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2021-07-13
- CAS:7463-51-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 4-Bromo-3,5-dimethylphenol
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- $15.00 / 1KG
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2021-07-09
- CAS:7463-51-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 4-Bromo-3,5-dimethylphenol Basic information |
| Product Name: | 4-Bromo-3,5-dimethylphenol | | Synonyms: | 4-BROMO-3,5-DIMETHYLPHENOL;4-BROMO-3,5-XYLENOL;4-bromo-3,5-dimethylphenol 4-Bromo-3,5-xylenol;3，5-Dimethyl-4-bromophenol;4-Bromo-3,5-dimethylphenol 99%;Phenol, 4-bromo-3,5-dimethyl-;4-Bromo-3,5-dimethylphenol,99%;4-BroMo-3,5-diMethylphenol, 99% 10GR | | CAS: | 7463-51-6 | | MF: | C8H9BrO | | MW: | 201.06 | | EINECS: | 231-255-8 | | Product Categories: | Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;blocks;Bromides;Aromatic Phenols;ketone;Phenol&Thiophenol&Mercaptan;Bromine Compounds;Phenols | | Mol File: | 7463-51-6.mol |  |
| | 4-Bromo-3,5-dimethylphenol Chemical Properties |
| Melting point | 113-115 °C(lit.) | | Boiling point | 195.33°C (rough estimate) | | density | 1.3646 (rough estimate) | | refractive index | 1.5650 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | form | Crystals or Powder | | pka | 9+-.0.23(Predicted) | | color | Colorless to slightly pink | | BRN | 2207127 | | InChI | InChI=1S/C8H9BrO/c1-5-3-7(10)4-6(2)8(5)9/h3-4,10H,1-2H3 | | InChIKey | WMUWDPLTTLJNPE-UHFFFAOYSA-N | | SMILES | C1(O)=CC(C)=C(Br)C(C)=C1 | | CAS DataBase Reference | 7463-51-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29081990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-Bromo-3,5-dimethylphenol Usage And Synthesis |
| Chemical Properties | COLORLESS TO SLIGHTLY PINK CRYSTALS OR POWDER | | Uses | 4-Bromo-3,5-dimethylphenol is used as a reactant in the synthesis of chromen-4-one and isoflavone scaffolds. | | Synthesis | General procedure for the synthesis of 4-bromo-3,5-dimethylphenol from 3,5-dimethylphenol: To a mixture of 3,5-dimethylphenol (0.7 mmol) was added a dichloromethane (30 mL)-methanol (15 mL) solution of brominating agent (1) (0.72 g, 0.7 mmol). The reaction mixture was stirred at room temperature until the orange solution faded. The progress of the reaction was monitored by thin layer chromatography (TLC) (eluent: hexane/ethyl acetate, 7:3). After completion of the reaction, the solvent was evaporated and ether (10 mL) was added to the residue. The supernatant was decanted and the insoluble residue was washed with ether (3 x 10 mL). The ether extracts were combined, dried with magnesium sulfate, and the solvent was evaporated under vacuum to obtain the crude 4-bromo-3,5-dimethylphenol. The target product was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate, 7:3). | | References | [1] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 440 - 447
[2] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 11, p. 4187 - 4189
[3] Synlett, 2011, # 15, p. 2265 - 2269
[4] Journal of the Iranian Chemical Society, 2016, vol. 13, # 11, p. 2019 - 2028
[5] Tetrahedron, 2007, vol. 63, # 34, p. 8242 - 8249 |
| | 4-Bromo-3,5-dimethylphenol Preparation Products And Raw materials |
| Raw materials | 3,5-Dimethyl-2,4-dibromophenol-->BDMC-->2-BroMo-3,5-diMethylphenol-->4-BROMO-3,5-DIMETHYLANISOLE-->3,5-Dimethylanisole-->Dichloromethane-->Methanol-->3,5-Dimethylphenol-->Acetic acid | | Preparation Products | (2,6-DIMETHYL-4-METHOXYPHENYL)BORONIC ACID-->tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate-->Benzoyl chloride, 4-ethoxy-2,6-dimethyl- (6CI,7CI)-->3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol-->2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile-->2,6-DIMETHYL-4'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL-4-OL-->2-bromo-1,3-dimethyl-5-pentoxybenzene |
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