Spirapril manufacturers
- Spirapril
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- $1980.00
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2026-05-11
- CAS:83647-97-6
- Purity:
- Supply Ability: 10g
- Spirapril
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2020-05-10
- CAS:83647-97-6
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 500 MT
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| | Spirapril Basic information |
| Product Name: | Spirapril | | Synonyms: | (8S-(7(R*(R*)),8R*))-7-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid;SPIRAPRIL;SPIRAPRIL FOR SYSTEM SUITABILITY EPY;SPIRAPRIL FOR SYSTEM SUITABILITY EPY(CRM STANDARD);1,4-Dithia-7-azaspiro(4,4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))-;Brn 4277924;Espirapril;Espirapril [spanish] | | CAS: | 83647-97-6 | | MF: | C22H30N2O5S2 | | MW: | 466.61 | | EINECS: | | | Product Categories: | | | Mol File: | 83647-97-6.mol |  |
| | Spirapril Chemical Properties |
| Boiling point | 697.8±55.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 2.99±0.20(Predicted) |
| | Spirapril Usage And Synthesis |
| Chemical Properties | Hemihydrate: white foamy substance. [α]D26-29.5° (C=0.2, ethanol). Spirapril Hydrochloride (Spirapril Hydrochloride): C22 H3ON2O5S2HCl.[94841-17-5]. White solid, melting point 192-194°C (decomposition). [α]D26-11.2° (C=0.4, ethanol). Spiraprilat (Spiraprilat): C20H26N2O5S2.[83602-05-5]. Diacid for spirapril. Semihydrate, melting point 163～165°C. [α]D26+4.1° (C=0.4, ethanol). | | Uses | Spirapril is an Angiotensin-converting enzyme inhibitor and used to treat high blood pressure. | | Definition | ChEBI: Spirapril is a dipeptide, a dithioketal, an azaspiro compound, a dicarboxylic acid monoester, an ethyl ester, a tertiary carboxamide, a secondary amino compound and a pyrrolidinecarboxylic acid. It has a role as a prodrug, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is functionally related to a spiraprilat. | | in vivo | Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice[2].
Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice[2].
Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments[2].
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats[3]. |
| | Spirapril Preparation Products And Raw materials |
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