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| Product Name: | SMAD4 | | Synonyms: | ANTI-SMAD4 antibody produced in mouse;Anti-SMAD4, N-Terminal antibody produced in rabbit;DPC4;MADH4;SMAD4;JIP;Deletion target in pancreatic carcinoma 4;SMAD4, GST tagged human | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![SMAD4 Structure]() |
| | SMAD4 Chemical Properties |
| storage temp. | -20°C | | form | Solid | | color | Light yellow to green yellow | | biological source | mouse |
| Storage Class | 10 - Combustible liquids |
| | SMAD4 Usage And Synthesis |
| Uses | cell analysis | | Biological Activity | Upon TGFβ (transforming growth factor β) activation, SMAD (mothers against decapentaplegic homolog) proteins are responsible for transcription activation in the nucleus. SMAD4 is a crucial protein of TGFβ signaling. It promotes association of SMAD2/4 to DNA and helps SMAD1/2 in transcription stimulation. Mutations in SMAD4 are linked with juvenile polyposis syndrome, hereditary haemorrhagic telangiectasia and Myhre syndrome. In renal cell carcinoma, it activates forkhead box protein H1 and thereby inhibits the progression of the carcinoma. SMAD4 is considered as a tumor suppressor protein. |
| | SMAD4 Preparation Products And Raw materials |
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