Fibronectin type III repeat-containing protein 2 (cleaved)

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Fibronectin type III repeat-containing protein 2 (cleaved) Basic information
Product Name:Fibronectin type III repeat-containing protein 2 (cleaved)
Synonyms:Fibronectin type III domain-containing protein 5 (cleaved);Fibronectin type III repeat-containing protein 2 (cleaved);CD121a;Irisin
CAS:1465928-51-1
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Fibronectin type III repeat-containing protein 2 (cleaved) Structure
Fibronectin type III repeat-containing protein 2 (cleaved) Chemical Properties
storage temp. -20°C
form lyophilized
Safety Information
WGK Germany WGK 2
Storage Class10 - Combustible liquids
MSDS Information
Fibronectin type III repeat-containing protein 2 (cleaved) Usage And Synthesis
UsesIrisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene encoding irisin is mapped to human chromosome 1p35.1.
Biological ActivityIrisin activates beige f at cells (beige cells have a gene expression pattern distinct from either white or brown f at and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white f at into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.
Fibronectin type III repeat-containing protein 2 (cleaved) Preparation Products And Raw materials
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