- 3-Cyano-4-fluorobenzaldehyde
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- $0.00 / 1kg
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2026-01-04
- CAS:218301-22-5
- Min. Order: 0.10000000149011612kg
- Purity: 99.0%min
- Supply Ability: 200kg
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| | 2-FLUORO-5-FORMYLBENZONITRILE Basic information |
| | 2-FLUORO-5-FORMYLBENZONITRILE Chemical Properties |
| Melting point | 80-84 °C (lit.) | | Boiling point | 215.6±20.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform, Methanol | | form | Solid | | color | White | | InChI | InChI=1S/C8H4FNO/c9-8-2-1-6(5-11)3-7(8)4-10/h1-3,5H | | InChIKey | MOFRJTLODZILCR-UHFFFAOYSA-N | | SMILES | C(#N)C1=CC(C=O)=CC=C1F | | CAS DataBase Reference | 218301-22-5(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | IRRITANT | | HS Code | 29269090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-FLUORO-5-FORMYLBENZONITRILE Usage And Synthesis |
| Description | 2-Fluoro-5-formylbenzonitrile is a pharmaceutical intermediate compound used in the preparation of Olaparib, a PARP inhibitor for the treatment of a variety of cancers including advanced ovarian, fallopian tube, or primary peritoneal cancers with a certain hereditary (germline) or acquired (somatic) abnormality of the BRCA gene. | | Chemical Properties | White Solid | | Uses | 2-Fluoro-5-ForMyl-benzonitrile is used in the preparation of heterocyclic compounds as PARP inhibitors for medical use. | | Uses |
2-Fluoro-5-formylbenzonitrile may be used in the synthesis of 3-cyano-4-fluorobenzyl bromide. It could be used to synthesis 2-fluoro-5-(4-ethoxybenzyl)benzonitrile. 2-Fluoro-5-formylbenzonitrile (10g, 1eq) was dissolved in 100mL 1,4-dioxane, p-toluenesulfonyl hydrazide (13.7g, 1eq) was added, stirred at room temperature for 3 hours, and then added Potassium carbonate (13.9 g, 1.5 eq), 4-ethoxyphenylboronic acid (12.2 g, 1 eq), warmed to 100 C. and stirred for 12 hours. After TLC monitoring the reaction of the raw materials, filter, spin dry the filtrate, add petroleum ether and stir for half an hour, filter, and spin dry the filtrate to obtain 15 g of 2-fluoro-5-(4-ethoxybenzyl)benzonitrile (the yield is 88%).
| | General Description | 2-Fluoro-5-formylbenzonitrile is a benzonitrile derivative. | | Synthesis | 2-Fluoro-5-formylbenzonitrile can be synthesized by reacting 3-bromo-4-fluoro-benzaldehyde with cuprous cyanide. | | Toxicity evaluation | 2-Fluoro-5-formylbenzonitrile has acute dermal toxicity and acute Inhalation toxicity.
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| | 2-FLUORO-5-FORMYLBENZONITRILE Preparation Products And Raw materials |
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