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| | 2-(Trifluoromethoxy)bromobenzene Basic information |
| | 2-(Trifluoromethoxy)bromobenzene Chemical Properties |
| Boiling point | 158-160 °C(lit.) | | density | 1.62 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.464(lit.) | | Fp | 140 °F | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | Colorless to Light yellow | | BRN | 1947768 | | InChI | 1S/C7H4BrF3O/c8-5-3-1-2-4-6(5)12-7(9,10)11/h1-4H | | InChIKey | ITYCJCVRPBLODP-UHFFFAOYSA-N | | SMILES | FC(F)(F)Oc1ccccc1Br | | CAS DataBase Reference | 64115-88-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39-37 | | RIDADR | UN1993 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29093090 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Flam. Liq. 3 |
| | 2-(Trifluoromethoxy)bromobenzene Usage And Synthesis |
| Uses | 1-Bromo-2-(trifluoromethoxy)benzene can be prepared from (trifluoromethoxy)benzene. | | General Description | 1-Bromo-2-(trifluoromethoxy)benzene can be prepared from (trifluoromethoxy)benzene. | | Synthesis | In a glove box, KF (78.4 mg, 1.35 mmol, 4.5 eq.) was added to a 20 mL polyethylene (PE) plastic tube. Subsequently, dicyclohexane-18-crown-6 (503 mg, 1.35 mmol, 4.5 eq.) and 6. Next, ethylidene precursor (0.3 mmol, 1.0 eq.), 1-bromophenylacetylene (218 mg, 1.2 mmol, 4.0 eq.) or perfluorohexyl bromide (479 mg, 1.2 mmol, 4.0 eq.) or pentafluorophenyl bromide ( 296 mg, 1.2 mmol, 4.0 equiv) and trifluoromethyl benzoate (171 mg, 0.9 mmol, 3.0 equiv). The reaction tube was sealed and the reaction was carried out at room temperature for 12 hours. At the end of the reaction, the F-spectral yield was first determined by 19F NMR. Finally, the reaction mixture was filtered, dried and purified directly by column chromatography. | | References | [1] Patent: CN108516935, 2018, A. Location in patent: Paragraph 0166; 0167; 0168; 0169; 0170; 0171
[2] Journal of the American Chemical Society, 2018, vol. 140, # 22, p. 6801 - 6805 |
| | 2-(Trifluoromethoxy)bromobenzene Preparation Products And Raw materials |
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