| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
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| | 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid Basic information |
| | 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid Chemical Properties |
| Boiling point | 297.4±40.0 °C(Predicted) | | density | 1.79±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 2.40±0.25(Predicted) | | Appearance | White to off-white Solid |
| | 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid Usage And Synthesis |
| Synthesis | c) Synthesis of 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid: Methyl 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylate (540 mg, 2.6 mmol) was dissolved in tetrahydrofuran (18 mL), and a mixture of aqueous and methanol (1:1, 12 mL) of lithium hydroxide (135 mg, 5.6 mmol) was slowly added at room temperature. After 1 h of reaction, most of the solvent was removed by concentration under reduced pressure. The residue was dissolved in water (10 mL) and acidified with 2 M hydrochloric acid to pH ≈ 2. Subsequent extraction with ethyl acetate, drying of the organic phase with anhydrous sodium sulfate, and concentration under reduced pressure afforded a white solid crude product (555 mg). The crude product was ground with pentane (10 mL), the solid was collected by filtration and washed with pentane and dried under reduced pressure to give 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid (477 mg, 95% yield). Mass spectrum (ISP): m/z = 195.0 [M-H] | | References | [1] Patent: US2011/144097, 2011, A1. Location in patent: Page/Page column 52
[2] Patent: WO2011/69934, 2011, A1. Location in patent: Page/Page column 102; 103
[3] Patent: WO2012/98064, 2012, A1. Location in patent: Page/Page column 87
[4] Patent: US2012/184540, 2012, A1. Location in patent: Page/Page column 46
[5] Patent: US2012/258962, 2012, A1. Location in patent: Page/Page column 45 |
| | 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials |
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