|
|
| | TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Basic information |
| Product Name: | TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE | | Synonyms: | Tetrahydro-2H-pyran-4-carboxamide ,98%;tetrahydropyran-4-carboxamide;3,4,5,6-Tetrahydro-2H-pyran-4-carboxamide;4-CARBAMOYLTETRAHYDROPYRAN;TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE;Tetrahydropyran-4-carboxamid;Tetrahydro-2H-pyran-4-carboxamide 98%;4-Carbamoyltetrahydro-2H-pyran | | CAS: | 344329-76-6 | | MF: | C6H11NO2 | | MW: | 129.16 | | EINECS: | | | Product Categories: | blocks;Carboxes;Heterocycles | | Mol File: | 344329-76-6.mol |  |
| | TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Chemical Properties |
| Melting point | 181-183 | | Boiling point | 312.1±31.0 °C(Predicted) | | density | 1.114 | | storage temp. | Sealed in dry,Room Temperature | | pka | 16.31±0.20(Predicted) | | form | solid | | color | White |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-20/21/22 | | Safety Statements | 24/25-36/37 | | Hazard Note | Irritant/Keep Cold | | HazardClass | IRRITANT | | HS Code | 29339900 |
| | TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis | The general procedure for the synthesis of tetrahydropyran-4-carboxamide from methyl tetrahydropyran-4-carboxylate was as follows: tetrahydro-2H-pyran-4-carboxylic acid methyl ester (7 g, 48.6 mmol) was mixed with 30% ammonia (20 mL) in a closed reaction flask, and the reaction was stirred at room temperature for 18 hours. Upon completion of the reaction, the excess ammonia was removed by distillation under reduced pressure and the residue was recrystallized from ethanol to give 5.6 g (89% yield) of the target product, tetrahydro-2H-pyran-4-carboxamide. The structure of the product was confirmed by 1H NMR (401 MHz, DMSO-d6) with chemical shifts δ ppm of 7.21 (br.s, 1H), 6.73 (br.s, 1H), 3.90-3.80 (m, 2H), 3.30-3.23 (m, 2H), 2.36-2.24 (m, 1H), 1.66-1.47 (m, 4H ). | | References | [1] Patent: WO2012/113774, 2012, A1. Location in patent: Page/Page column 41-42
[2] Patent: US2013/324551, 2013, A1. Location in patent: Paragraph 0326; 0327
[3] ChemMedChem, 2015, vol. 10, # 2, p. 276 - 295
[4] Patent: WO2015/62486, 2015, A1. Location in patent: Paragraph 00325
[5] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 45 |
| | TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Preparation Products And Raw materials |
|