4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:FEMA 4774 NEW
CAS:1359963-68-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:FEMA 4774
CAS:1359963-68-0
Purity:99.97% Package:1mg;40USD|5mg;88USD|10mg;137USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
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Products Intro: Product Name:FEMA 4774；S9632
CAS:1359963-68-0
Package:1 mg；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
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Products Intro: Product Name:FEMA 4774
CAS:1359963-68-0
Purity:98% Package:$49.9/1mg;$139.9/5mg;$209.9/10mg;$410.9/25mg;$606.9/50mg;Bulk package Remarks:98%
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
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Products Intro: Product Name:FEMA4774
CAS:1359963-68-0
Purity:98% Package:5mg Remarks:S89085

4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid manufacturers

  • FEMA 4774
  • FEMA 4774 pictures
  • $40.00 / 1mg
  • 2026-04-21
  • CAS:1359963-68-0
  • Min. Order:
  • Purity: 99.97%
  • Supply Ability: 10g
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Basic information
Product Name:4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid
Synonyms:4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid;EOS-60517;FEMA 4774; FEMA 4774 NEW;4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Properties;3-Quinolinecarboxylic acid, 4-amino-5-[2,2-dimethyl-3-[(1-methylethyl)amino]-3-oxopropoxy]-2-methyl-;S9632;Inhibitor,positive allosteric modulator,sucrose,weetness enhancer,FEMA-4774,T1R3,inhibit,FEMA4774,FEMA 4774,T1R2
CAS:1359963-68-0
MF:C19H25N3O4
MW:359.42
EINECS:
Product Categories:
Mol File:1359963-68-0.mol
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Structure
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Chemical Properties
FEMA 4774 | 4-AMINO-5-(3-(ISOPROPYLAMINO)-2,2-DIMETHYL-3-OXOPROPOXY)-2-METHYLQUINOLINE-3-CARBOXYLIC ACID
storage temp. Store at -20°C
solubility DMSO : ≥ 41.67 mg/mL (115.94 mM)
form Solid
color White to off-white
Odormilky dairy
JECFA Number2204
Safety Information
MSDS Information
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Usage And Synthesis
UsesFEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer[1].
in vivo

FEMA 4774 (S9632) (oral gavage, 500-2000 mg/kg) does not cause a dose-dependent increase in polychromatic erythrocytes and induces micronuclei formation at dose levels up to 2000 mg/kg in Swiss albino (CD-1) mice[2].
The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats

RouteDayDose (mg/kg)SexCmax (ng/mL)±SDTmax (hr)t1/2 (hr)AUC0last(nghr/mL)AUC0last/dose(nghr/mL/mg/kg)%F
iv11.0M2036.7±281.90.030.19330.6±58330.6-
F2625.8±679.90.030.27411.9±116.3411.9-
Oral gavage110M12.9±3.20.251.2117.9±2.31.790.54
F34.0±3.90.251.1749.2±7.84.921.19
30M90.0±23.90.330.8890.8±11.03.030.92
F62.4±25.90.421.0695.0±20.43.170.77
100M147.2±86.30.330.71176.2±73.81.760.53
F268.5±90.70.250.99341.1±81.03.410.83
Oral gavage710M16.2±3.60.500.8448.1±33.24.81-
F32.7±9.70.331.1758.9±25.45.89-
30M74.5±16.20.330.9486.0±8.72.87-
F77.1±41.70.251.39106.8±8.73.56-
100M117.9±15.30.250.72185.3±15.31.85-
F189.7±79.50.250.89278.9±79.02.79-
References[1] Guy Servant, et al. The function and allosteric control of the human sweet taste receptor. Adv Pharmacol. 2020;88:59-82. DOI:10.1016/bs.apha.2020.01.002
[2] Amy J Arthur, et al. Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid. Toxicol Rep. 2015 Sep 3;2:1255-1264. DOI:10.1016/j.toxrep.2015.08.012
4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylicacid Preparation Products And Raw materials
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