- N3-PEG12-Tos
-
- $0.00 / 1g
-
2026-02-05
- CAS:1821464-56-5
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
- Azide-PEG12-Tos
-
- $29.00 / 2mg
-
2026-01-05
- CAS:1821464-56-5
- Min. Order:
- Purity: 98.72%
- Supply Ability: 10g
- Azido-PEG12-Tos
-
- $0.00 / 1g
-
2025-06-07
- CAS:1821464-56-5
- Min. Order: 1g
- Purity: >95.00%
- Supply Ability: 1g
|
| | Azide-PEG12-Tos Basic information |
| Product Name: | Azide-PEG12-Tos | | Synonyms: | Azide-PEG12-Tos;N3-PEG12-Tos;2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate;Azido-PEG12-Tos;Azide PEG12 Tos,AzidePEG12Tos,Inhibitor,Azide-PEG-12-Tos,PROTAC Linkers,inhibit;N3-PEG12-Tos/3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontan-1-ol, 35-azido-, 1-(4-methylbenzenesulfonate);35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl 4-methylbenzenesulfonate | | CAS: | 1821464-56-5 | | MF: | C31H55N3O14S | | MW: | 725.85 | | EINECS: | | | Product Categories: | | | Mol File: | 1821464-56-5.mol |  |
| | Azide-PEG12-Tos Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF |
| | Azide-PEG12-Tos Usage And Synthesis |
| Description | Azide-PEG12-Tos is a monodisperse PEG reagent containing an azide group and a tosyl group. Long PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic reactions. | | Uses | Azide-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG12-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azide-PEG12-Tos Preparation Products And Raw materials |
|