| Company Name: |
InvivoChem |
| Tel: |
+1-708-310-1919 +1-13798911105 |
| Email: |
sales@invivochem.cn |
|
| | AZD9056 (hydrochloride) Basic information |
| Product Name: | AZD9056 (hydrochloride) | | Synonyms: | AZD9056 (hydrochloride);AZD-9056 HCl;AZD-9056 HYDROCHLORIDE; AZD 9056 HYDROCHLORIDE;AZD9056 hydrochloride,AZD 9056,AZD-9056,P2X Receptor,P2XRs,Inhibitor,AZD-9056 hydrochloride,AZD9056,inhibit;AZD 9056 HCl - Bio-X;AZD9056 hydrochloride, 10 mM in DMSO;N-(goldalkane-1-ylmethyl)-2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)benzamidehydrochloride | | CAS: | 345303-91-5 | | MF: | C24H36Cl2N2O2 | | MW: | 455.46 | | EINECS: | | | Product Categories: | | | Mol File: | 345303-91-5.mol |  |
| | AZD9056 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : ≥ 34 mg/mL (74.65 mM) | | form | Solid | | color | White to off-white |
| | AZD9056 (hydrochloride) Usage And Synthesis |
| Uses | AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. | | in vivo | Treatment with AZD9056 exerts pain-relieving and anti-inflammatory effects. The upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP) and prostaglandin E2 (PGE2) which is induced by MIA in cartilage tissues is reversed by AZD9056[3]. | | IC 50 | P2X7 Receptor | | References | [1] Seeland S, et al. ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacol Res Perspect. 2015 Mar;3(2):e00123. DOI:10.1002/prp2.123
[2] Elsby R, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011 May 18;43(1-2):41-9. DOI:10.1016/j.ejps.2011.03.006
[3] Hu H, et al. Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med. 2016 Dec;38(6):1922-1932. DOI:10.3892/ijmm.2016.2770 |
| | AZD9056 (hydrochloride) Preparation Products And Raw materials |
|