- TPI-1
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- $46.00 / 1mg
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2026-01-24
- CAS:79756-69-7
- Min. Order:
- Purity: 99.64%
- Supply Ability: 10g
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| | 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Basic information |
| Product Name: | 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione | | Synonyms: | TPI-1;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;TPI1;TPI 1;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;Recombinant Human TIM/TPI1 Protein, His Tag;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;TPI-1,Inhibitor,inhibit,Phosphatase;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione | | CAS: | 79756-69-7 | | MF: | C12H6Cl2O2 | | MW: | 253.08 | | EINECS: | | | Product Categories: | | | Mol File: | 79756-69-7.mol |  |
| | 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | color | White to yellow | | InChI | 1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H | | InChIKey | ZKHFYORNAYYOTM-UHFFFAOYSA-N | | SMILES | O=C1C=CC(C(C2=C(C=CC(Cl)=C2)Cl)=C1)=O |
| WGK Germany | WGK 3 | | HS Code | 2914698090 | | Storage Class | 11 - Combustible Solids |
| | 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Usage And Synthesis |
| Uses | TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM. | | Biological Activity | TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent SHP-1 inhibitor with IC50 of 40 nM for recombinant SHP-1. It has anticancer activity. | | in vitro | SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. It selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ < sup> + cells in human peripheral blood. | | in vivo | TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. It thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated sc agent. | | target | | Target | Value | SHP-1
(Cell-free assay) | 40 nM |
| | References | [1] Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36. DOI:10.4049/jimmunol.0903562 |
| | 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Preparation Products And Raw materials |
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