2-HYDRAZINOQUINOLINE manufacturers
- 2-HYDRAZINOQUINOLINE
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- $0.00 / 1KG
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2021-10-15
- CAS:15793-77-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 tons
- 2-HYDRAZINOQUINOLINE
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- $1.00 / 1KG
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2019-12-20
- CAS:15793-77-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: Kg/T
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| | 2-HYDRAZINOQUINOLINE Basic information |
| | 2-HYDRAZINOQUINOLINE Chemical Properties |
| Melting point | 142°C | | Boiling point | 303.1±45.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in methanol. | | pka | 5.41±0.20(Predicted) | | form | powder to crystal | | color | Light yellow to Brown | | CAS DataBase Reference | 15793-77-8(CAS DataBase Reference) | | EPA Substance Registry System | 2(1H)-Quinolinone, hydrazone (15793-77-8) |
| Provider | Language |
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ALFA
| English |
| | 2-HYDRAZINOQUINOLINE Usage And Synthesis |
| Uses | 2-Hydrazinoquinoline acts as as a derivatization agent for LC-MS-based metabolomic investigation of diabetic ketoacidosis. It is used in agrochemical, pharmaceutical and dyestuff field. | | Synthesis | The general procedure for the synthesis of 2-hydrazinoquinoline from 2-chloroquinoline was as follows: 21.0 g (128.4 mmol) of 2-chloroquinoline was first dissolved in 210 mL of ethanol. Subsequently, 64.3 g (1.3 mol) of hydrazine hydrate was added and the reaction mixture was stirred under reflux conditions for 16 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the precipitated solid product was collected by filtration and washed with a small amount of ethanol. After initial drying, the product was further dried under high vacuum. Finally, 14.5 g of product was obtained in 71% yield. The product was analyzed by LC-MS (Method 1): retention time Rt = 1.95 min; mass spectrum (ESIpos): m/z = 160 [M + H]+; 1H-NMR (400 MHz, DMSO-d6) data were as follows: δ= 8.08 (broad peaks, 1H), 7.87 (double peaks, 1H), 7.63 (double peaks, 1H), 7.57-7.43 (multiple peaks, 2H), 7.16 (triple peaks, 1H), 6.85 (double peaks, 1H), 4.35 (broad peaks, 2H). | | References | [1] Patent: US2012/264704, 2012, A1. Location in patent: Page/Page column 17
[2] Journal of the Chemical Society, 1913, vol. 103, p. 1981
[3] Journal of the Indian Chemical Society, 1981, vol. 58, p. 840 - 843
[4] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2006, vol. 65, # 2, p. 463 - 466
[5] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007, vol. 66, # 4-5, p. 972 - 975 |
| | 2-HYDRAZINOQUINOLINE Preparation Products And Raw materials |
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