|
|
| | Phe-Met-Arg-Phe amide trifluoroacetate Basic information |
| Product Name: | Phe-Met-Arg-Phe amide trifluoroacetate | | Synonyms: | Phe-Met-Arg-Phe amide trifluoroacetate;Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%;PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98% | | CAS: | 159237-99-7 | | MF: | C31H43F3N8O6S | | MW: | 712.79 | | EINECS: | | | Product Categories: | | | Mol File: | 159237-99-7.mol |  |
| | Phe-Met-Arg-Phe amide trifluoroacetate Chemical Properties |
| storage temp. | Store at -20°C | | form | Solid | | color | White to off-white | | Water Solubility | Water : ≥ 50 mg/mL (60.47 mM) | | Sequence | H-Phe-Met-Arg-Phe-NH2 |
| | Phe-Met-Arg-Phe amide trifluoroacetate Usage And Synthesis |
| Uses | Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons. | | in vivo | Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min[3]. | | References | [1] Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. DOI:10.1085/jgp.110.5.611
[2] Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. DOI:10.1016/0196-9781(84)90021-4
[3] Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. DOI:10.1016/0143-4179(87)90054-0 |
| | Phe-Met-Arg-Phe amide trifluoroacetate Preparation Products And Raw materials |
|