DBCO-PEG4-NHS ester
| 中文名称 | DBCO-PEG4-NHS ester |
|---|---|
| 中文同义词 | 4,7,10,13-四氧化酸,20-(11,12-丁酰二苯肼[B,F]偶氮-5(6H)-烯酰)-16,20-二氧化硅-,2,5-二氧氧基-1-吡咯烷基酯;二苯并环辛炔-PEG4-丙酸琥珀酰亚胺酯;二苯并环辛炔-NHCO-四聚乙二醇-活性酯;化合物 DBCO-NHCO-PEG4-NHS ester;二苯并环辛炔-酰胺-四聚乙二醇-琥珀酰亚胺酯;DBCO-NHCO-PEG4-琥珀酰亚胺酯 |
| 英文名称 | DBCO-PEG4-NHS ester |
| 英文同义词 | 4,7,10,13-Tetraoxa-17-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-16,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 1-[(3-{2-azatricyclo[10.4.0.0\\u2074,\\u2079]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)carbamoyl]-3,6,9,12-tetraoxapentadecan-15-oate;DBCO-NHCO-PEG4-NHS ester |
| CAS号 | 2100306-58-7 |
| 分子式 | C34H39N3O10 |
| 分子量 | 649.69 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2100306-58-7.mol |
| 结构式 |  |
DBCO-PEG4-NHS ester 性质
| 密度 | 1.33±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 15.14±0.46(Predicted) |
DBCO-NHCO-PEG4-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。DBCO-NHCO-PEG4-NHS ester 可用于合成一系列 PROTAC 分子。DBCO-NHCO-PEG4-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
|
Cleavable
|
PEGs
|
Alkyl/ether
|
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.