4-Amino-2-chlorobenzonitrile

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CAS:20925-27-3

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4-Amino-2-chlorobenzonitrile Basic information
Product Name:4-Amino-2-chlorobenzonitrile
Synonyms:TIMTEC-BB SBB004052;LABOTEST-BB LT00159892;4-AMINO-2-CHLOROBENZONITRILE;3-CHLORO-4-CYANOANILINE;4-Amino-2-chlorobenzonitrile 99%;4-AMINO-2-CHLOROBENZONITRILE, 98+%;4-azanyl-2-chloro-benzenecarbonitrile;4-Amino-2-chlorobenzonitrile >
CAS:20925-27-3
MF:C7H5ClN2
MW:152.58
EINECS:244-114-0
Product Categories:Nitrile;Aromatic Nitriles
Mol File:20925-27-3.mol
4-Amino-2-chlorobenzonitrile Structure
4-Amino-2-chlorobenzonitrile Chemical Properties
Melting point 116-118 °C(lit.)
Boiling point 339.5±27.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka0.67±0.10(Predicted)
color White to Light yellow to Light orange
BRN 2936425
InChI1S/C7H5ClN2/c8-7-3-6(10)2-1-5(7)4-9/h1-3H,10H2
InChIKeyZFBKYGFPUCUYIF-UHFFFAOYSA-N
SMILESNc1ccc(C#N)c(Cl)c1
CAS DataBase Reference20925-27-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi,N
Risk Statements 22-43
Safety Statements 22-24/25-36/37
RIDADR 3439
WGK Germany 3
Hazard Note Harmful/Irritant
HazardClass 6.1
PackingGroup III
HS Code 2926907090
Storage Class11 - Combustible Solids
Hazard ClassificationsSkin Sens. 1
MSDS Information
ProviderLanguage
4-Amino-2-chlorobenzonitrile English
SigmaAldrich English
ALFA English
4-Amino-2-chlorobenzonitrile Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powder
Uses4-Amino-2-chlorobenzonitrile is commonly used as an organic reagent.
Synthesis
2-Chloro-4-nitrobenzonitrile

28163-00-0

4-Amino-2-chlorobenzonitrile

20925-27-3

Step 4: 2-chloro-4-nitrobenzonitrile (5 g, 0.027 mol) was mixed with hydrazine monohydrate (110 ml) and heated to reaction initiation. Subsequently, the remaining 2-chloro-4-nitrobenzonitrile (35 g, 0.192 mol) was added in batches. The reaction mixture was refluxed for about 30 min after the nitrogen release stopped completely. Upon completion of the reaction, the mixture was slowly poured into stirred ice water. The precipitate was collected by filtration and purified by recrystallization in water to give 2-chloro-4-aminobenzonitrile (25 g, 78% yield, melting point 117 °C).

References[1] Patent: US4424371, 1984, A
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