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ENALAPRILAT DIHYDRATE

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Company Name: Henan Fengda Chemical Co., Ltd
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CAS:84680-54-6
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CAS: 84680-54-6
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ENALAPRILAT DIHYDRATE manufacturers

  • Enalaprilat Dihydrate
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  • $0.00 / 1g/Bag
  • 2026-05-22
  • CAS:84680-54-6
  • Min. Order: 1g
  • Purity: 98%-101%
  • Supply Ability: 500G
  • Enalaprilat Dihydrate
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  • $33.00 / 25mg
  • 2026-04-21
  • CAS:84680-54-6
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  • Purity: 99.46%
  • Supply Ability: 10g
  • Enalaprilat Dihydrate
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  • $850.00 / 500mg
  • 2025-12-10
  • CAS:84680-54-6
  • Min. Order: 1mg
  • Purity: 99 %
  • Supply Ability: 500 Kg
ENALAPRILAT DIHYDRATE Basic information
Product Name:ENALAPRILAT DIHYDRATE
Synonyms:(S)-1-[N-[1-(CARBOXY)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE, DIHYDRATE;MK-422;ENALAPRILAT DIHYDRATE;ENALAPRILATE;Enalaprilate USP25;ENALAPRILAT USP;Enalaprilat (300 mg);Enalaprilic Acid Dihydrate
CAS:84680-54-6
MF:C18H26N2O6
MW:366.41
EINECS:689-724-1
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Inhibitors
Mol File:84680-54-6.mol
ENALAPRILAT DIHYDRATE Structure
ENALAPRILAT DIHYDRATE Chemical Properties
Melting point 151-159°C
alpha [α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis)
storage temp. 2-8°C
solubility H2O: soluble14mg/mL at 60°C (warming for 5 minutes)
form Solid
color White to Off-White
Water Solubility H2O: 14mg/mL at60°C (warming for 5 minutes)
DMSO: 64mg/mL
InChIKeyMFNXXPRUKGSARH-MTPBSTKNNA-N
SMILESC(N1CCC[C@H]1C(=O)O)(=O)[C@H](C)N[C@H](C(=O)O)CCC1C=CC=CC=1.O |&1:5,10,13,r|
CAS DataBase Reference84680-54-6(CAS DataBase Reference)
EPA Substance Registry SystemL-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6)
Safety Information
WGK Germany 3
RTECS TW3590600
HS Code 2933995300
Storage Class11 - Combustible Solids
MSDS Information
ENALAPRILAT DIHYDRATE Usage And Synthesis
DescriptionAngiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.
Chemical PropertiesWhite Solid
Usesanthelmintic
UsesActive metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor. Enalapril EP Impurity C (Dihydrate).
DefinitionChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
Biochem/physiol ActionsEnalapril, the ethyl ester ofenalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver toenalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.
References[1] PIERRE REDELINGHUYS  EDWARD D S  ALOYSIUS T NCHINDA. Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors[J]. Annals of the New York Academy of Sciences, 2006, 1056 1: 160-175. DOI: 10.1196/annals.1352.035
[2] JAMES J. MENCEL. Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives[J]. Journal of Medicinal Chemistry, 1990, 33 6: 1606-1615. DOI: 10.1021/jm00168a013
ENALAPRILAT DIHYDRATE Preparation Products And Raw materials
Tag:ENALAPRILAT DIHYDRATE(84680-54-6) Related Product Information
Enalaprilat Triphosgene Ethyl trans-3-Benzoylacrylate Enalapril EP IMpurity A (SSR) L-Proline (R,S,S)-Enalapril L-Alanine Enalapril diketopiperazine (αS)-Cyclohexanebutanoic Acid α-[[(1S)-1-Carboxyethyl]aMino] cyclohexanebutanoic Acid α-Ethyl Ester Ethyl 3-benzoylacrylate Phenylsilane Dimethylimidazole Phenyltrichlorosilane MOEXIPRIL HYDROCHLORIDE Fosinopril sodium Belinostat (PXD101) CHLOROPHENYLSILANE Cilazapril Monohydrate