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| | 3-NITRO-2-PYRIDINESULFENYL CHLORIDE Basic information |
| | 3-NITRO-2-PYRIDINESULFENYL CHLORIDE Chemical Properties |
| Melting point | 205 °C (dec.) (lit.) | | Boiling point | 376.8±27.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | dichloromethane: soluble(lit.) | | pka | -3.72±0.29(Predicted) | | InChI | 1S/C5H3ClN2O2S/c6-11-5-4(8(9)10)2-1-3-7-5/h1-3H | | InChIKey | WTKQMHWYSBWUBE-UHFFFAOYSA-N | | SMILES | [O-][N+](=O)c1cccnc1SCl |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-27-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B |
| | 3-NITRO-2-PYRIDINESULFENYL CHLORIDE Usage And Synthesis |
| Uses | 3-Nitro-2-pyridinesulfenyl chloride (NpysCl) was employed as the starting material for the synthesis of N-, O- and S-Npys-protected amino acid. | | Preparation | 3-Nitro-2-pyridinesulfenyl chloride may be prepared by chlorination of bis(3-nitro-2-pyridyl) disulfide with gaseous chlorine. | | General Description | The 3-nitro-2-pyridinesulphenyl (Npys) moiety is useful as a protecting-activating group for cysteine, particularly in the synthesis of cyclic and unsymmetrical disulfides. The stability of NpysCl was studied in various solvents. | | storage | moisture sensitive, but stable for several weeks at rt under dry conditions; no decomposition is seen after 6 months in a refrigerator. | | Purification Methods | The chloride crystallises as yellow needles from CH2Cl2. When pure, it is stable for several weeks at room temperature, and no decomposition was observed after 6 months at <0o. It is moisture sensitive. UV (MeCN) has at 231nm max ( 12,988), 264nm ( 5,784) and 372nm ( 3,117). [NMR and UV: Matsuda & Aiba Chem Lett 951 1978, Wagner et al. Chem Ber 75 935 1942.] |
| | 3-NITRO-2-PYRIDINESULFENYL CHLORIDE Preparation Products And Raw materials |
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