[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone

Request For Quotation
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: Anhui JYHX CO., LTD.  
Tel: 055167162561 13295518198
Email: wangyanan@ahjyhx.com
Company Name: Zhejiang Huida Biotech Co., Ltd.  
Tel: 0571-89903022 18679456698
Email: zilong@hizyme.com
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Basic information
Product Name:[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone
Synonyms:[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone;SKI-349
CAS:727686-80-8
MF:C19H19N3O4S
MW:385.43686
EINECS:
Product Categories:
Mol File:727686-80-8.mol
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Structure
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Chemical Properties
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Usage And Synthesis
DescriptionSKI-349 is a novel dual-targeted inhibitor of sphingosine kinase and microtubule polymerization.
UsesSKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells[1][2].
References[1] Hengst JA, et al. Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127453. DOI:10.1016/j.bmcl.2020.127453
[2] Chen L, et al. SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma. Tohoku J Exp Med. 2023 Dec 21. DOI:10.1620/tjem.2023.J100
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Preparation Products And Raw materials
Tag:[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone(727686-80-8) Related Product Information
1-(4-amino-2-anilino-1,3-thiazol-5-yl)ethanone Methanone, [4-amino-2-[(4-methoxyphenyl)amino]-5-thiazolyl](2-methoxyphenyl)- Methanone, [4-amino-2-[(2-ethylphenyl)amino]-5-thiazolyl]phenyl- [4-Amino-2-(4-chloroanilino)-1,3-thiazol-5-yl](phenyl)methanone [4-amino-2-(phenylamino)-5-thiazolyl]phenylmethanone AKOS USSH-4110200