H-GLY-NHME HCL manufacturers
- H-GLY-NHME HCL
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- $1.00 / 1KG
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2020-01-10
- CAS:49755-94-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kg
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| | H-GLY-NHME HCL Basic information |
| Product Name: | H-GLY-NHME HCL | | Synonyms: | GLYCINE-N-METHYLAMIDE HYDROCHLORIDE;GLYCINE-NHME HCL;GLYCINE METHYLAMIDE HYDROCHLORIDE;H-GLY-NHME HCL;2-AMINO-N-METHYLACETAMIDE HYDROCHLORIDE;H-Gly-nhme hydrochloride;N-Methyl-glycine amide, 2-Amino-N-methylacetamide hydrochloride;2-AMINO-N-METHYLACETAMIDE HYDR | | CAS: | 49755-94-4 | | MF: | C3H9ClN2O | | MW: | 124.57 | | EINECS: | | | Product Categories: | Amino Acids | | Mol File: | 49755-94-4.mol |  |
| | H-GLY-NHME HCL Chemical Properties |
| Melting point | 154-156℃ | | storage temp. | Inert atmosphere,2-8°C | | form | Powder | | color | Off-white |
| Hazard Codes | Xn | | Risk Statements | 22 | | HazardClass | IRRITANT |
| | H-GLY-NHME HCL Usage And Synthesis |
| Uses | 2-Amino-N-methylacetamide is an intermediate used to prepare macrocyclic hydroxamic acids that inhibit tumor necrosis factor α. It is also used to synthesize 2-[(arylalkyl)amino]alkanamide derivatives with anticonvulsant activities. | | Synthesis | Tert-butyl N-[(methylcarbamoyl)methyl]carbamate (300 mg, 1.59 mmol, 1.00 eq.) was dissolved in dichloromethane (5 mL), hydrochloric acid (1.2 mL) was added, and the reaction was stirred for 4 hours at room temperature. After completion of the reaction, the mixture was concentrated under vacuum to give 2-amino-N-methylacetamide hydrochloride (185 mg), the product was a colorless oil. Mass spectrum (MS): m/z 89 (M + H)+. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3): δ 8.45 (br s, 1H), 8.19 (s, 3H), 3.50 (d, 2H), 2.65 (d, 3H). | | References | [1] Journal of the American Chemical Society, 1992, vol. 114, # 12, p. 4834 - 4843
[2] Journal de Chimie Physique et de Physico-Chimie Biologique, 1988, vol. 85, # 5, p. 583 - 588
[3] Patent: WO2013/106535, 2013, A1. Location in patent: Paragraph 00571 |
| | H-GLY-NHME HCL Preparation Products And Raw materials |
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