| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:AMG-1694
CAS:1361217-07-3
Purity:97.00% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:AMG-1694
CAS:1361217-07-3
Purity:97.97% Package:1mg/RMB 2670;5mg/RMB 6360;10mg/RMB 8690
|
(2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-ol manufacturers
- AMG-1694
-
- $160.00 / 1mg
-
2025-10-26
- CAS:1361217-07-3
- Min. Order:
- Purity: 97.94%
- Supply Ability: 10g
- AMG-1694
-
- $160.00 / 1mg
-
2025-10-26
- CAS:1361217-07-3
- Min. Order:
- Purity: 97.94%
- Supply Ability: 10g
|
| | (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-ol Basic information |
| | (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-ol Chemical Properties |
| Boiling point | 652.6±65.0 °C(Predicted) | | density | 1.348±0.06 g/cm3(Predicted) | | form | Solid | | pka | 12.89±0.15(Predicted) | | color | Off-white to light yellow |
| | (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-ol Usage And Synthesis |
| Description | AMG-1694 is a potent GK-GKRP disruptor. | | Uses | AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. | | References | [1] Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40. DOI:10.1038/nature12724 |
| | (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-ol Preparation Products And Raw materials |
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