1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea

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1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea manufacturers
1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea Basic information
Product Name:1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea
Synonyms:1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea;N-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-N'-(4-methylphenyl)urea;cyt-PTPε Inhibitor-1;Urea, N-[5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-N'-(4-methylphenyl)-;Cyt-PTPε Inhibitor-1, 10 mM in DMSO;OPREA1_650507;1-[5-(2,4-Dimethyl-phenoxymethyl)-[1,3,4]thiadiazol-2-yl]-3-p-tolyl-urea
CAS:428478-94-8
MF:C19H20N4O2S
MW:368.4527
EINECS:
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Mol File:428478-94-8.mol
1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea Structure
1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea Chemical Properties
density 1.319±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka7.07±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea Usage And Synthesis
Usescyt-PTPε Inhibitor-1 is a potent cytosolic protein tyrosine phosphatase epsilon (cyt-PTPε) inhibitor, binds to the catalytic domain of cyt-PTPε, blocks c-Src activation (dephosphorylation of c-Src), and exhibits anti-osteoclastic activity[1].
References[1] Ku B, et al. Identification of N-(5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as novel protein tyrosine phosphatase epsilon inhibitors exhibiting anti-osteoclastic activity. ioorg Med Chem. 2018 Oct 1;26(18):5204-5211. DOI:10.1016/j.bmc.2018.09.022
1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea Preparation Products And Raw materials
Tag:1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea(428478-94-8) Related Product Information
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