- Ascomycin
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2026-03-29
- CAS:11011-38-4
- Min. Order:
- Purity: 0.99
- Supply Ability:
- Ascomycin
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- $5.00/ KG
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2026-03-27
- CAS:11011-38-4
- Min. Order: 1KG
- Purity: 99% hplc
- Supply Ability: 500TONS
- Ascomycin
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- $0.00 / 25g
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2026-01-04
- CAS:11011-38-4
- Min. Order: 100g
- Purity: 99.5%
- Supply Ability: 100kg
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| Product Name: | Ascomycin | | Synonyms: | ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS;ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS;FR-900520;FK-520;IMMUNOMYCIN;AAG;ASCOMYCIN (IMMUNOMYCIN, FR-900520) \ INH IBITS CALCINEURIN (PP2B);(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone | | CAS: | 11011-38-4 | | MF: | C43H69NO12 | | MW: | 792.01 | | EINECS: | 658-052-0 | | Product Categories: | API;Immunosuppressant | | Mol File: | 11011-38-4.mol |  |
| | Ascomycin Chemical Properties |
| Melting point | 158 - 161°C | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming). | | form | White crystalline solid | | color | White | | biological source | goat | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| WGK Germany | WGK 2 | | RTECS | CI7570000 | | Storage Class | 10 - Combustible liquids |
| | Ascomycin Usage And Synthesis |
| Description | Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo. | | Chemical Properties | White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from biological fermentation. | | Uses | A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases. | | General Description | An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells. | | Biochem/physiol Actions | Product does not compete with ATP. | | Enzyme inhibitor | This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4;
Solubility: 50 mM in DMSO), also known as FK520, isolated from
Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note
that ascomycin is a structural analogue of tacrolimus (or FK506) and, as
such, operates by a similar mechanism of action (See Tacrolimus).
Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin
phosphatase activity. | | Background | Ascomycin is a 23-membered macrolide lactone produced from the fermentation of Streptomyces hygroscopicus. A natural analogue of FK506, Ascomycin has the ability to bind to FK506-binding protein 12, inhibiting calcineurin phosphatase activity, and disrupting the activation of nuclear factor of activated T cells and other various substrates. Primarily described as an antifungal antibiotic, Ascomycin has shown to be a potent immunosuppressant used to prevent the rejection of organ transplants and skin allografts. Ascomycin displays powerful antimalarial properties independent of its immunosuppressive mechanisms of action. | | References | [1] H HATANAKA. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.[J]. Journal of Antibiotics, 1988, 41 11: 1592-1601. DOI:10.7164/antibiotics.41.1592
[2] A. M. PETROS. NMR studies of an FK-506 analog [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding[J]. Journal of Medicinal Chemistry, 1991, 34 9: 2925-2928. DOI:10.1021/jm00113a037
[3] KARL W. MOLLISON. A Macrolactam Inhibitor of T Helper Type 1 and T Helper Type 2 Cytokine Biosynthesis for Topical Treatment of Inflammatory Skin Diseases1[J]. Journal of Investigative Dermatology, 1999, 112 5: Pages 729-738. DOI:10.1046/j.1523-1747.1999.00567.x |
| | Ascomycin Preparation Products And Raw materials |
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