克利溴铵
| 中文名称 | 克利溴铵 |
|---|---|
| 中文同义词 | (1-甲基-1-氮杂双环[2.2.2]辛-8-基) 2-羟基-2,2-二苯基乙酸酯溴化物;可立啶;克利溴铵;溴奎环二苯酯;克利溴铵 标准品;克利溴铵 USP标准品;3-(2-羟基-2,2-二苯基乙酰氧基)-1-甲基奎宁-1-鎓溴化物;克利溴铵|||RO 2-3773 |
| 英文名称 | Clidinium bromide |
| 英文同义词 | CLIDINIUM BROMIDE;3-[(HYDROXYPHENYLACETYL)OXY]-1-METHYL-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE;3-HYDROXY-1-METHYLQUINUCLIDINIUM BROMIDE BENZILATE;QUARZAN;RO-2-3773;quinuclidinolmethylbromide,benzilate;3-[(Hydroxyphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2,2,2]octane Bromide, Ro-2-3773, Quarzan;Clidinium |
| CAS号 | 3485-62-9 |
| 分子式 | C22H26BrNO3 |
| 分子量 | 432.35 |
| EINECS号 | 222-471-3 |
| 相关类别 | 医药中间体;法医和兽医标准品;小分子抑制剂;医药原料;QUARZAN;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 3485-62-9.mol |
| 结构式 |  |
克利溴铵 性质
| 熔点 | 240-241°C |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（轻微、超声处理）、水（轻微） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| CAS 数据库 | 3485-62-9(CAS DataBase Reference) |
Clidinium bromide 是一种季胺抗毒蕈碱 (antimuscarinic) 剂。Clidinium bromide 可以通过减少胃酸和减慢肠道速度来缓解痉挛和腹部/胃疼的症状。
Clidinium (oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days) causes constipation in mice. It leads to a significant decrease in %transit after clidinium treatment [(F(3, 28)=27.405] in mice.Clidinium (oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days) has a significant effect on the clonic seizure threshold induced by intravenous PTZ which received clidinium (0.25, 0.5, and 1 mg/kg) [(F(3, 35) = 14.103].
| Animal Model: | Male NMRI mice weighing 20-25 g |
| Dosage: | 0.25, 0.5, and 1 mg/kg |
| Administration: | Oral gavage; 0.25, 0.5, and 1 mg/kg; 3 days |
| Result: | Decreased the clonic seizure latency compared with control animals. |