ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Bromopyridine >3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE

3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE

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3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Suppliers list
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:3-Bromo-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine
CAS:452972-13-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE
CAS:452972-13-3
Purity:99% Package:1KG;1USD
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Products Intro: Product Name:3-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS:452972-13-3
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-22101
Company Name: Wuhan Chemwish Technology Co., Ltd
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Products Intro: Product Name:5-Bromopyridine-3-boronic acid,pinacol ester
CAS:452972-13-3
Purity:0.98 Package:1g;5g;25g;2087g
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:5-Bromo-3-pyridineboronic acid pinacol ester
CAS:452972-13-3
Purity:0.99 Package:1kg

3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE manufacturers
3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Basic information
Product Name:3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE
Synonyms:5-BROMO-3-PYRIDINEBORONIC ACID PINACOL &;5-BROMOPYRIDINE-3-BORONIC ACID, PINACOL ESTER;5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;5-Bromo-3-pyridineboronic acid pinacol ester;3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-y98%;3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE;3-BROMOPYRIDINE-5-BORONIC ACID PINACOL ESTER;Pyridine, 3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS:452972-13-3
MF:C11H15BBrNO2
MW:283.96
EINECS:201-525-2
Product Categories:
Mol File:452972-13-3.mol
3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Structure
3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Chemical Properties
Melting point 63.4-63.8°C
Boiling point 341.4±27.0 °C(Predicted)
density 1.34
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka2.86±0.22(Predicted)
AppearanceWhite to off-white Solid
Safety Information
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26
WGK Germany 3
HazardClass IRRITANT
HS Code 2933399990
MSDS Information
3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Usage And Synthesis
Synthesis
3,5-Dibromopyridine

625-92-3

Bis(pinacolato)diboron

73183-34-3

3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE

452972-13-3

Preparation of compound 4-1 (5-bromopyridine-3-boronic acid pinacol ester) [221]: In a dry reaction flask 3,5-dibromopyridine (25 g, 105.5 mmol), pinacol ester of biboronic acid (28 g, 110.8 mmol), PdCl2(PPh3)2 (3.7 g, 5.27 mmol), and KOAc (20.7 g 211 mmol), and then 1,4-dioxane (211 mL) was added. The reaction mixture was stirred at reflux for 2 h at 120 °C. After completion of the reaction, it was cooled to room temperature and the organic layer was extracted with ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by column chromatography to afford compound 4-1 (25 g, 86% yield) as a white solid.

References[1] Patent: WO2016/186321, 2016, A1. Location in patent: Paragraph 220-221
3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Preparation Products And Raw materials
Raw materials3,5-Dibromopyridine-->Bis(pinacolato)diboron-->Potassium Acetate-->Bis(triphenylphosphine)palladium(II) chloride-->1,4-Dioxane
Preparation Products3-Bromo-5-hydroxypyridine
Tag:3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE(452972-13-3) Related Product Information
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 5-Bromopyridine-3-boronic acid 2-BROMO-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-BROMO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 3-BROMO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 2-BROMO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 5-BROMO-2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 5-BROMO-2-METHOXY-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 5-BROMO-2-FLUORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 5-BROMO-2-TERT-BUTYLOXYCARBONYLAMINO PYRIDINE-3-BORONIC ACID PINACOL ESTER 5-BROMO-2-TERT-BUTYLOXYCARBONYLAMINO-6-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER 5-BROMO-2-CHLORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE 3-BROMO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 2,5-DIBROMOPYRIDINE-3-BORONIC ACID PINACOL ESTER