- 2-Bromoquinoline
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- $1.10 / 1g
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2025-11-18
- CAS:2005-43-8
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- 2-Bromoquinoline
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- $10.00 / 1KG
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2021-10-15
- CAS:2005-43-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 tons
- 2-Bromoquinoline
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- $15.00 / 1KG
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2021-07-13
- CAS:2005-43-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 2-Bromoquinoline Basic information |
| | 2-Bromoquinoline Chemical Properties |
| Melting point | 44-48 °C | | Boiling point | 115°C/0.3mmHg(lit.) | | density | 1.564±0.06 g/cm3(Predicted) | | Fp | >110℃ | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | pka | 0.58±0.40(Predicted) | | form | powder to crystal | | color | White to Light yellow | | λmax | 319nm(EtOH)(lit.) | | InChI | InChI=1S/C9H6BrN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H | | InChIKey | QKJAZPHKNWSXDF-UHFFFAOYSA-N | | SMILES | N1C2C(=CC=CC=2)C=CC=1Br | | CAS DataBase Reference | 2005-43-8(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-36/37/38-41-37/38-22 | | Safety Statements | 26-36-39-22 | | WGK Germany | 3 | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2-Bromoquinoline Usage And Synthesis |
| Chemical Properties | White powder | | Synthesis | The general procedure for the synthesis of 2-bromoquinoline from 1-methyl-2-quinolone was as follows: Triphenylphosphine (1186 mg, 4.52 mmol) and dibromoisocyanuric acid (652 mg, 2.27 mmol) were sequentially added to a 50 mL round bottom flask fitted with a magnetic stirrer and a balloon (for pressure equilibrium) under nitrogen protection. The mixture was heated to 115 °C, at which point the dibromoisocyanuric acid reacted vigorously, and the reaction was continued to maintain this temperature for 10 min. Subsequently, 1-methylquinolin-2(1H)-one (239 mg, 1.50 mmol) was added to the reaction system and the temperature of the reaction was raised to 160-170°C for 16 hours. After completion of the reaction, the reaction mixture was dissolved in dichloromethane and alkalized with triethylamine. Purification was carried out by silica gel column chromatography with hexane-ethyl acetate (6:1, v/v) as eluent to finally obtain 2-bromoquinoline (244 mg, 78% yield). 2-bromoquinoline was a yellow oil, and its 1H-NMR (CDCl3) data were as follows: δ 7.51 (1H, d, J = 8.4 Hz), 7.51-8.20 (4H, m), 7.98 ( 1H, d, J = 8.4Hz). | | References | [1] Heterocycles, 2015, vol. 91, # 7, p. 1445 - 1454 |
| | 2-Bromoquinoline Preparation Products And Raw materials |
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