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| | 3-Fluoropyridine-4-carboxylic acid Basic information |
| | 3-Fluoropyridine-4-carboxylic acid Chemical Properties |
| Melting point | 251-254°C (dec.) | | Boiling point | 360.0±22.0 °C(Predicted) | | density | 1.419±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | solid | | pka | 2.85±0.10(Predicted) | | color | White to off-white | | BRN | 383678 | | InChI | 1S/C6H4FNO2/c7-5-3-8-2-1-4(5)6(9)10/h1-3H,(H,9,10) | | InChIKey | POLXLLIQWDBJMD-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccncc1F | | CAS DataBase Reference | 393-53-3(CAS DataBase Reference) |
| Hazard Codes | Xi,F | | Risk Statements | 36/37/38-10 | | Safety Statements | 26-36-16 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 | | Storage Class | 13 - Non Combustible Solids |
| | 3-Fluoropyridine-4-carboxylic acid Usage And Synthesis |
| Synthesis | 3-Fluoropyridine (25 g, 257 mmol) was slowly added dropwise to a solution of tetrahydrofuran (600 mL) containing butyl lithium (270 mmol) and diisopropylamine (27.4 g, 271 mmol) at -78 °C. The reaction mixture was stirred continuously at this temperature for 1 hour. Subsequently, crushed dry ice was added to the reaction system and gradually warmed to room temperature over 1 hour. Upon completion of the reaction, the pH of the reaction solution was adjusted to 5 with an aqueous solution of hydrogen chloride and acidified. The resulting precipitate was collected by filtration and dried. The final 3-fluoroisonicotinic acid (25.2 g, 179 mmol, 70% yield) was obtained as colorless crystals. | | References | [1] Patent: WO2006/36015, 2006, A2. Location in patent: Page/Page column 121-122 |
| | 3-Fluoropyridine-4-carboxylic acid Preparation Products And Raw materials |
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