|
|
| | 2-Amino-5-nitrophenol Basic information |
| | 2-Amino-5-nitrophenol Chemical Properties |
| Melting point | 198-202 °C (dec.) (lit.) | | Boiling point | 322.46°C (rough estimate) | | density | 1.3617 (estimate) | | refractive index | 1.6890 (rough estimate) | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 8.08±0.19(Predicted) | | form | Crystalline Powder | | color | Rust brown to brown | | Water Solubility | insoluble | | BRN | 972974 | | Cosmetics Ingredients Functions | HAIR DYEING | | Cosmetic Ingredient Review (CIR) | 2-Amino-5-nitrophenol (121-88-0) | | InChI | InChI=1S/C6H6N2O3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H,7H2 | | InChIKey | DOPJTDJKZNWLRB-UHFFFAOYSA-N | | SMILES | C1(O)=CC([N+]([O-])=O)=CC=C1N | | CAS DataBase Reference | 121-88-0(CAS DataBase Reference) | | IARC | 3 (Vol. 57) 1993 | | EPA Substance Registry System | 2-Amino-5-nitrophenol (121-88-0) |
| | 2-Amino-5-nitrophenol Usage And Synthesis |
| Chemical Properties | Brown to rust Crystalline powder | | Uses | Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2 | | Uses | 2-Amino-5-nitrophenol is used in hair dyes and as an intermediate
in preparing azo dyes. | | Uses | 2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes. | | Definition | ChEBI: 2-Amino-5-nitrophenol is a member of 3-nitrophenols. | | General Description | Brown amorphous granules or powder. Melting point 198-202°C. | | Air & Water Reactions | Is slowly oxidized by air at room temperature. Insoluble in water. | | Reactivity Profile | 2-Amino-5-nitrophenol is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides. | | Fire Hazard | Flash point data for 2-Amino-5-nitrophenol are not available. 2-Amino-5-nitrophenol is probably combustible. | | Carcinogenicity | The potential carcinogenicity of 2-amino-5-nitrophenol
was tested by NTP by oral administration (gavage) in
corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1
mice (400 and 800 mg/kg) for 2 years. There was some
evidence of carcinogenic activity in low-dose male rats, as
indicated by increased incidence of acinar cell adenomas of
the pancreas. No evidence of carcinogenic activity was found
among female rats and the low-dose groups of male and
female mice. The poor survival rates in the high-dose male
rats and high-dose male and female mice reduced the sensitivity
for detecting potential carcinogenic response. | | Purification Methods | Crystallise the phenol from water. [Beilstein 13 IV 803.] |
| | 2-Amino-5-nitrophenol Preparation Products And Raw materials |
|