- 5-FLUORO-2-IODOPYRIDINE
-
- $1.10 / 1g
-
2025-11-18
- CAS:159870-80-1
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
- 5-Fluoro-2-iodopyridine
-
- $0.00 / 25kg
-
2024-03-28
- CAS:159870-80-1
- Min. Order: 25kg
- Purity: 98%
- Supply Ability: Inquiry
- 5-Fluoro-2-iodopyridine
-
- $0.00 / 100G
-
2022-08-13
- CAS:159870-80-1
- Min. Order: 0.0001G
- Purity: 98%min
- Supply Ability: 50kgs/month
|
| | 5-Fluoro-2-iodopyridine Basic information |
| | 5-Fluoro-2-iodopyridine Chemical Properties |
| Boiling point | 197℃ | | density | 2.046 | | Fp | 73℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | -0.58±0.10(Predicted) | | color | yellow to off-white solid |
| | 5-Fluoro-2-iodopyridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-fluoro-2-iodopyridine from 2-bromo-5-fluoropyridine: under nitrogen protection, Cu2O (7.2 mg, 10 mol%), L-proline (11.5 mg, 20 mol%), 2-bromo-5-fluoropyridine (0.50 mmol), potassium iodide (KI, 249 mg, 0.75 mmol) and ethanol (EtOH, 1.5 mL). After sealing the Schlenk tube with a PTFE valve, the reaction mixture was stirred at 110 °C. The reaction process was monitored by gas chromatography (GC) analysis. Upon completion of the reaction, the yield was determined by GC using an appropriate internal standard (e.g., chlorobenzene or 1-chloro-4-methylbenzene) for highly volatile products; or the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether/ethyl acetate = 10/1) to give the target product 5-fluoro-2-iodopyridine. | | References | [1] Catalysis Today, 2016, vol. 274, p. 129 - 132 |
| | 5-Fluoro-2-iodopyridine Preparation Products And Raw materials |
|