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| | 2-(Dimethylamino)pyridine-5-boronic acid hydrate Basic information |
| | 2-(Dimethylamino)pyridine-5-boronic acid hydrate Chemical Properties |
| Boiling point | 352.3±52.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 4.21±0.10(Predicted) | | color | Yellow |
| Hazard Codes | Xi,Xn | | Risk Statements | 22 | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 2-(Dimethylamino)pyridine-5-boronic acid hydrate Usage And Synthesis |
| Uses | 2-(Dimethylamino)pyridine-5-boronic acid, hydrade | | Synthesis | General procedure for the synthesis of 2-(dimethylamino)pyridine-5-boronic acid from 5-bromo-N,N-dimethylpyridin-2-amine and pinacol ester of bis(boronic acid): to a solution of 1,4-dioxane (20 mL) in 5-bromo-N,N-dimethylpyridin-2-amine (400 mg, 1.989 mmol), was added sequentially 4,4,4',4',5,5,5',5'-octa methyl-2,2'-bis(1,3,2-dioxaborolane) (606 mg, 2.387 mmol), PdCl2(dppf)-CH2Cl2 adduct (162 mg, 0.199 mmol) and potassium acetate (390 mg, 3.98 mmol). The reaction mixture was heated to 100 °C and stirred overnight under nitrogen protection. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum to afford the crude product (6-(dimethylamino)pyridin-3-yl)boronic acid (420 mg, 0.496 mmol, 25% yield) as a brown oil.LCMS analysis showed the [M+H]+ peak at 167.1. | | References | [1] Patent: WO2017/98440, 2017, A1. Location in patent: Page/Page column 170 |
| | 2-(Dimethylamino)pyridine-5-boronic acid hydrate Preparation Products And Raw materials |
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