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| | 7-(4-Chlorobenzyl)-8-{[2-(1H-indol-3-yl)ethyl]amino}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Basic information |
| Product Name: | 7-(4-Chlorobenzyl)-8-{[2-(1H-indol-3-yl)ethyl]amino}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione | | Synonyms: | TOSLAB 870931;1H-Purine-2,6-dione, 7-[(4-chlorophenyl)methyl]-3,7-dihydro-8-[[2-(1H-indol-3-yl)ethyl]amino]-1,3-dimethyl-;PSB-KK1415;7-(4-Chlorobenzyl)-8-{[2-(1H-indol-3-yl)ethyl]amino}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione | | CAS: | 885896-26-4 | | MF: | C24H23ClN6O2 | | MW: | 462.93 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![7-(4-Chlorobenzyl)-8-{[2-(1H-indol-3-yl)ethyl]amino}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Structure](StructureFile/ChemBookStructure9/GIF/CB5464502.gif) |
| | 7-(4-Chlorobenzyl)-8-{[2-(1H-indol-3-yl)ethyl]amino}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Chemical Properties |
| Boiling point | 729.2±70.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | form | Solid | | pka | 17.17±0.30(Predicted) | | color | White to off-white |
| | 7-(4-Chlorobenzyl)-8-{[2-(1H-indol-3-yl)ethyl]amino}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Usage And Synthesis |
| Uses | PSB-KK1415 is a selective agonist for human orphan G protein-coupled receptor GPR18, with EC50 of 19.1 nM[1]. | | References | [1] Mahardhika AB, et al., Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity. J Med Chem. 2024 Jun 27;67(12):9896-9926. DOI:10.1021/acs.jmedchem.3c02423 |
| | 7-(4-Chlorobenzyl)-8-{[2-(1H-indol-3-yl)ethyl]amino}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Preparation Products And Raw materials |
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