| Company Name: |
BOC Sciences
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16314854226 |
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info@bocsci.com |
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Product Name:WOBE437
CAS:2108100-73-6
Purity:97% Package:1G;10G;100G Remarks:WOBE437 is a potent endocannabinoid uptake inhibitor with IC50 values of 10 and 283 nM for arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG) uptake, respectively, in U937 cells.
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| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
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Product Name:WOBE437
CAS:2108100-73-6
Package:5mg/RMB 6230;1mg/RMB 1410;10mg/RMB 11000
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| Company Name: |
Cayman Chemical Company
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800-364-9897 |
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sales@caymanchem.com |
| Products Intro: |
Product Name:WOBE437
CAS:2108100-73-6
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| Company Name: |
Merck KGaA
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21-20338288 |
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ordercn@merckgroup.com |
| Products Intro: |
Product Name:WOBE437
CAS:2108100-73-6
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| | WOBE437 Basic information |
| Product Name: | WOBE437 | | Synonyms: | WOBE437;2,4-Dodecadienamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-, (2E,4E)-;(2E,4E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dodecadienamide;(2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide | | CAS: | 2108100-73-6 | | MF: | C22H33NO3 | | MW: | 359.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2108100-73-6.mol |  |
| | WOBE437 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 2.5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml | | form | A crystalline solid | | color | white to beige |
| | WOBE437 Usage And Synthesis |
| Description | WOBE437 is a potent endocannabinoid uptake inhibitor with IC50 values of 10 and 283 nM for arachidonoyl ethanolamide (AEA; ) and 2-arachidonoyl glycerol (2-AG; ) uptake, respectively, in U937 cells. It is greater than 1,000-fold selective for endocannabinoid transporters over fatty acid amide hydrolase (FAAH; ) and the 2-AG hydrolyzing enzymes MAGL, ABHD6, and ABHD12. WOBE437 inhibits AEA uptake in FAAH-deficient HMC-1 human mast cells and Neuro2a mouse neuroblastoma cells (IC50s = 137 and 55 nM, respectively) and reduces AEA uptake by 50% in rat cortical neurons when used at a concentration of 1 μM. It also reduces 2-AG uptake by 40% in Neuro2a cells at a concentration of 5 μM. In vivo, WOBE437 increases AEA and 2-AG levels by 1.5-fold in mouse brain but not peripheral tissues after intraperitoneal administration of a 10 mg/kg dose for seven days. WOBE437 (10 mg/kg) also induces a typical tetrad of hypothermia, catalepsy, analgesia, and hypomotility in mice, indicating it also acts as an indirect cannabinoid (CB) receptor 1 agonist. | | Uses | WOBE437 is a biochemical reagent. | | References | [1] ANDREA CHICCA. Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 25: E5006-E5015. DOI: 10.1073/pnas.1704065114 |
| | WOBE437 Preparation Products And Raw materials |
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