| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
|
| | GAK inhibitor 49 Basic information |
| Product Name: | GAK inhibitor 49 | | Synonyms: | GAK inhibitor 49;4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)-;6,7-Dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine;NAK,selective,GAK inhibitor-49,GAK inhibitor49,GAK inhibitor 49,Inhibitor,inhibit,ATP-competitive,family;AK inhibitor 49;GAK inhibitor 49, 10 mM in DMSO | | CAS: | 319492-82-5 | | MF: | C20H22N2O5 | | MW: | 370.4 | | EINECS: | | | Product Categories: | | | Mol File: | 319492-82-5.mol |  |
| | GAK inhibitor 49 Chemical Properties |
| Boiling point | 494.8±45.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 50 mg/mL (134.99 mM; ultrasonic and warming and heat to 80°C) | | form | Solid | | pka | 7+-.0.50(Predicted) | | color | White to off-white |
| | GAK inhibitor 49 Usage And Synthesis |
| Uses | GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2[1]. | | References | [1] Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66. DOI:10.1002/cmdc.201700663 |
| | GAK inhibitor 49 Preparation Products And Raw materials |
|