| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:GNE-207
CAS:2158266-58-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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GNE-207 manufacturers
- GNE-207
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- $1690.00
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2026-07-14
- CAS:2158266-58-9
- Purity:
- Supply Ability: 10g
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| | GNE-207 Basic information |
| Product Name: | GNE-207 | | Synonyms: | GNE-207;2-Pyridinecarboxamide, 5-[8-[5-acetyl-4,5,6,7-tetrahydro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-3-isoquinolinyl]-N-methyl-;GNE 207,GNE207 | | CAS: | 2158266-58-9 | | MF: | C29H30N6O3 | | MW: | 510.59 | | EINECS: | | | Product Categories: | | | Mol File: | 2158266-58-9.mol |  |
| | GNE-207 Chemical Properties |
| Boiling point | 812.8±65.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 200 mg/mL (391.70 mM) | | form | Solid | | pka | 13.75±0.46(Predicted) | | color | White to off-white |
| | GNE-207 Usage And Synthesis |
| Description | GNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50=1nM, MYC EC50=18nM), and it exhibits a good pharmacokinetic profile. | | Uses | GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, exhibits a selectively index of >2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells[1]. | | in vivo | GNE-207 (5 mg/kg) shows moderate clearance in PK, with acceptable oral bioavailability[1]. | | IC 50 | BRD4(1): 3.1 μM (IC50); CBP: 1 nM (IC50) | | References | [1] Lai KW, et al. Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300. ioorg Med Chem Lett. 2018 Jan 1;28(1):15-23. DOI:10.1016/j.bmcl.2017.11.025 |
| | GNE-207 Preparation Products And Raw materials |
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