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| | TBK1 PROTAC 1 Basic information |
| Product Name: | TBK1 PROTAC 1 | | Synonyms: | TBK1 PROTAC 1;PROTAC TBK1 C3i;TBK1 PROTAC?3i;L-Prolinamide, N-[2-[3-[4-[3-[4-[[5-bromo-4-[[3-[(cyclobutylcarbonyl)methylamino]propyl]amino]-2-pyrimidinyl]amino]phenoxy]propoxy]butoxy]propoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | | CAS: | 2052306-13-3 | | MF: | C53H74BrN9O9S | | MW: | 1093.19 | | EINECS: | | | Product Categories: | | | Mol File: | 2052306-13-3.mol |  |
| | TBK1 PROTAC 1 Chemical Properties |
| density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO|109.32|100| | | form | Solid | | pka | 13.61±0.46(Predicted) | | color | White to off-white |
| | TBK1 PROTAC 1 Usage And Synthesis |
| Uses | PROTAC TBK1 degrader-2 is a Ligands for Target Protein for PROTAC. PROTAC TBK1 degrader-2 is a potent degrader based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) (DC50=15 nM; Kd=4.6 nM) with a maximum efficiency of 96%. PROTAC TBK1 degrader-2 also targets to IkB kinase IKKε (IC50=8.7 nM), with low selectivity over TBK1 (IC50=1.3 nM)[1]. | | storage | Store at -20°C | | References | [1] Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61(2):583-598. DOI:10.1021/acs.jmedchem.7b00635 |
| | TBK1 PROTAC 1 Preparation Products And Raw materials |
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