| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:Nebracetam hydrochloride
CAS:1177279-49-0
Package:1ml Remarks:T95203
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| Company Name: |
Fan De(Beijing) Biotechnology Co., Ltd.
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| Tel: |
15911056312 |
| Email: |
liming@bio-fount.com |
| Products Intro: |
Product Name:4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride
CAS:1177279-49-0
Purity:97.0% Package:5mg
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4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride manufacturers
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| | 4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride Basic information |
| Product Name: | 4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride | | Synonyms: | 4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride;Nebracetam hydrochloride;WEB 1881 FU hydrochloride;Alzheimer's,Inhibitor,mAChR,Ca2+,inhibit,Nebracetam hydrochloride,Muscarinic acetylcholine receptor,2-DG,Nebracetam,2-deoxyglucose,WEB 1881 FU;Nebracetam hydrochloride, 10 mM in DMSO | | CAS: | 1177279-49-0 | | MF: | C12H17ClN2O | | MW: | 240.73 | | EINECS: | | | Product Categories: | | | Mol File: | 1177279-49-0.mol |  |
| | 4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride Chemical Properties |
| storage temp. | Store at -20°C, protect from light, sealed storage, away from moisture | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | 4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride Usage And Synthesis |
| Uses | Nebracetam hydrochloride, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca2+]i[1]. | | in vivo | Nebracetam (10 mg/kg, p.o.) involves not only cholinergic mechanisms but also involves lymbic and hippocampal noradrenergic mechanisms[2]. | Animal Model: | Male Wistar rats weighing 200-250 g[2]. | | Dosage: | 10, 20 mg/kg. | | Administration: | P.O. (single dose). | | Result: | Able to correct this scopolamine-induced disruption of spatial cognition. |
| | References | [1] Kitamura Y, et al. Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. Jpn J Pharmacol. 1991 Jan;55(1):177-80. DOI:10.1254/jjp.55.177
[2] Iwasaki K, et al. Effect of nebracetam on the disruption of spatial cognition in rats. Jpn J Pharmacol. 1992 Feb;58(2):117-26. DOI:10.1254/jjp.58.117 |
| | 4-(aminomethyl)-1-benzylpyrrolidin-2-one hydrochloride Preparation Products And Raw materials |
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