SHIN1 manufacturers
- SHIN1
-
-
2026-08-19
- CAS:2146095-85-2
- Min. Order: 1KG
- Purity: 98
- Supply Ability: 1000 KG
- SHIN1
-
- $71.00
-
2026-07-14
- CAS:2146095-85-2
- Purity: 98.96%
- Supply Ability: 10g
- SHIN1
-
- $71.00
-
2026-07-14
- CAS:2146095-85-2
- Purity: 98.96%
- Supply Ability: 10g
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| Product Name: | SHIN1 | | Synonyms: | SHIN1;Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-;RZ-2994;SHIN1,RZ2994,SHIN-1,RZ 2994,Inhibitor,SHIN 1,inhibit;6-Amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;{5-[6-amino-3,5-dimethyl-4-(propan-2-yl)-1H,4H-pyrano[2,3-c]pyrazol-4-yl]-[1,1'-biphenyl]-3-yl}methanol;SHIN1, 10 mM in DMSO;6-amino-4-(5-(hydroxymethyl)-[1,1'-biphenyl]-3-yl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | | CAS: | 2146095-85-2 | | MF: | C24H24N4O2 | | MW: | 400.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2146095-85-2.mol |  |
| | SHIN1 Chemical Properties |
| Boiling point | 683.6±55.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | pka | 11.54±0.70(Predicted) | | color | White to off-white |
| | SHIN1 Usage And Synthesis |
| Uses | SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. | | storage | Store at -20°C | | References | [1] Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. DOI:10.1073/pnas.1706617114 |
| | SHIN1 Preparation Products And Raw materials |
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