- 2-Chloro-6-fluorobenzaldehyde
-
- $5.00 / 1KG
-
2025-09-25
- CAS:387-45-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | 2-Chloro-6-fluorobenzaldehyde Basic information |
| | 2-Chloro-6-fluorobenzaldehyde Chemical Properties |
| Melting point | 32-35 °C(lit.) | | Boiling point | 92 °C (10 mmHg) | | density | 1.3310 (estimate) | | Fp | 215 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Crystalline Solid | | color | White to yellow | | Water Solubility | Insoluble | | Sensitive | Air Sensitive | | BRN | 2245530 | | InChI | InChI=1S/C7H4ClFO/c8-6-2-1-3-7(9)5(6)4-10/h1-4H | | InChIKey | OACPOWYLLGHGCR-UHFFFAOYSA-N | | SMILES | C(=O)C1=C(F)C=CC=C1Cl | | CAS DataBase Reference | 387-45-1(CAS DataBase Reference) | | EPA Substance Registry System | Benzaldehyde, 2-chloro-6-fluoro- (387-45-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 1 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29130000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | 2-Chloro-6-fluorobenzaldehyde Usage And Synthesis |
| Chemical Properties | whitetoyellowcrystallinesoli | | Uses | 2-Chloro-6-fluorobenzaldehyde was used in the synthesis of novel copolymers of methyl 2-cyano-3-dihalophenyl-2-propenoates and styrene. | | General Description | 2-Chloro-6-fluorobenzaldehyde undergoes piperidine catalyzed Knoevenagel condensation reaction with methyl cyanoacetate to yield methyl 2-cyano-3-dihalophenyl-2-propenoate. | | Synthesis | GENERAL METHOD: A mixture of 2-chloro-6-fluorobenzyl alcohol (1.0 mmol), N-phenylglycine (0.0076 g, 0.05 mmol), CuBr2 (0.0112 g, 0.05 mmol), Na2CO3 (0.1060 g, 1.0 mmol), and TEMPO (0.0078 g, 0.05 mmol) was added to a 100 mL Schlenk tube with H2O (3.0 mL) was added to a 100 mL Schlenk tube. It was stirred vigorously for 0.5 h under reflux conditions in air. After completion of the reaction, the product was extracted with CH2Cl2 (3 x 2.0 mL). The organic phases were combined, washed with H2O (3.0 mL) and dried with anhydrous MgSO4. After vacuum concentration, the residue was purified by column chromatography to give 2-chloro-6-fluorobenzaldehyde. Isolated yield: 0.1080 g (90%). | | References | [1] Synthetic Communications, 2008, vol. 38, # 15, p. 2638 - 2645
[2] Journal of the American Chemical Society, 2011, vol. 133, # 42, p. 16901 - 16910
[3] RSC Advances, 2014, vol. 4, # 90, p. 48777 - 48782
[4] Journal of Organic Chemistry, 2015, vol. 80, # 21, p. 11184 - 11188
[5] Synlett, 2015, vol. 26, # 6, p. 779 - 784 |
| | 2-Chloro-6-fluorobenzaldehyde Preparation Products And Raw materials |
|