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| | DC1-SMe Basic information |
| Product Name: | DC1-SMe | | Synonyms: | DC1-SMe;1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-;DC1SMe,DC-1SMe | | CAS: | 501666-85-9 | | MF: | C35H30ClN5O4S2 | | MW: | 684.23 | | EINECS: | | | Product Categories: | | | Mol File: | 501666-85-9.mol |  |
| | DC1-SMe Chemical Properties |
| Boiling point | 961.4±65.0 °C(Predicted) | | density | 1.522±0.06 g/cm3(Predicted) | | pka | 9.47±0.40(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | DC1-SMe Usage And Synthesis |
| Uses | DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer. | | IC 50 | Duocarmycins | | References | [1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m |
| | DC1-SMe Preparation Products And Raw materials |
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