17-phenyl trinor Prostaglandin F2α ELISA Kit

Request For Quotation
17-phenyl trinor Prostaglandin F2α ELISA Kit Suppliers list
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
17-phenyl trinor Prostaglandin F2α ELISA Kit Basic information
Product Name:17-phenyl trinor Prostaglandin F2α ELISA Kit
Synonyms:17-phenyl trinor Prostaglandin F2α ELISA Kit
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
17-phenyl trinor Prostaglandin F2α ELISA Kit Structure
17-phenyl trinor Prostaglandin F2α ELISA Kit Chemical Properties
Safety Information
MSDS Information
17-phenyl trinor Prostaglandin F2α ELISA Kit Usage And Synthesis
Description17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1 At the rat recombinant FP receptor expressed in CHO cells, 17-phenyl trinor PGF2α inhibits PGF2α binding with a Ki value of 1.1 nM.2 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. 17-phenyl trinor PGF2α ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.3 Whether 17-phenyl trinor PGF2α ethyl amide is a prodrug analogous to prostaglandin ester prodrugs such as latanoprost is currently controversial. There is some evidence that unmetabolized 17-phenyl trinor PGF2α is a weak FP receptor agonist.4 17-phenyl trinor PGF2α is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours.5 Cayman’s 17-phenyl trinor PGF2α ELISA is a sensitive detection method for measuring both the free acid and ethyl amide forms of 17-phenyl trinor PGF2α. The assay is most appropriate for use when only one of the two forms is present. Samples containing mixtures of both the ethyl amide and free acid should be purified and the two compounds separated prior to ELISA analysis.Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.WARNING This product is not for human or veterinary use.
17-phenyl trinor Prostaglandin F2α ELISA Kit Preparation Products And Raw materials
Tag:17-phenyl trinor Prostaglandin F2α ELISA Kit Related Product Information
Prostaglandin E Metabolite ELISA Kit Prostaglandin F2α ELISA Kit 13,14-dihydro-15-keto Prostaglandin F2α ELISA Kit 17-Phenyl trinor prostaglandin f2alpha 11β-Prostaglandin F2α ELISA Kit