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| | Pro-Adrenomedullin (45-92) (human) (trifluoroacetate salt) Basic information |
| | Pro-Adrenomedullin (45-92) (human) (trifluoroacetate salt) Chemical Properties |
| solubility | Formic Acid: 1 mg/ml |
| | Pro-Adrenomedullin (45-92) (human) (trifluoroacetate salt) Usage And Synthesis |
| Description | Proadrenomedullin (45-92) (MR-proADM) is a peptide that is comprised of amino acid residues 45-92 of preproadrenomedullin.1 MR-proADM has no effect on precontracted isolated cat pulmonary arterial rings when used at concentrations up to 10 μM, unlike adrenomedullin (1-52) (Item No. 24889) and adrenotensin, which induce relaxation and contraction, respectively.2 Levels of MR-proADM are elevated in the plasma of patients with sepsis and those with cardiovascular disease and positively correlate with disease severity in patients with community-acquired pneumonia.1,3WARNING This product is not for human or veterinary use. | | References | [1] NILS G MORGENTHALER. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay.[J]. Clinical chemistry, 2005, 51 10: 1823-1829. DOI: 10.1373/clinchem.2005.051110 [2] BULENT GUMUSEL . Adrenotensin: An ADM gene product with the opposite effects of ADM[J]. Life sciences, 1995, 57 8: Pages PL87-PL90. DOI: 10.1016/0024-3205(95)02012-8 [3] DAVID T HUANG. Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia.[J]. Chest, 2009, 136 3: 823-831. DOI: 10.1378/chest.08-1981 |
| | Pro-Adrenomedullin (45-92) (human) (trifluoroacetate salt) Preparation Products And Raw materials |
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